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Neutropenia is a significant dose-limiting toxicity of cancer
chemotherapy, especially in dose-intensified regimens. It is
widely treated by injections of Granulocyte Colony-Stimulating
Factor (G-CSF). However, optimal schedules of G-CSF administration
are still not determined. In order to aid in identifying more
efficacious and less neutropenic treatment protocols, we studied a
detailed physiologically-based computer model of granulopoiesis,
as affected by different treatment schedules of doxorubicin...
The circulatory system is one of the
first to function during development. The earliest event in the
system's development is vasculogenesis, whereby vascular
progeniter cells form clusters called blood islands, which later
fuse to form capillary networks. There exists a very good
in vitro system that mimics this process. When HUVECs
(Human Umbilical Vein Endothelial Cells) are cultured on Matrigel,
they spontaneously form a capillary network structure. Two
theoretical models have been proposed...
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