We present and compare two simple models of immune system and cancer cell interactions. The first model reflects simple cancer disease progression and serves as our "control" case. The second describes the progression of a cancer disease in the case of a patient infected with the HIV-1 virus.
Solid tumors and hematological cancers contain small population of tumor cells that are believed to play a critical role in the development and progression of the disease. These cells, named Cancer Stem Cells (CSCs), have been found in leukemia, myeloma, breast, prostate, pancreas, colon, brain and lung cancers. It is also thought that CSCs drive the metastatic spread of cancer. The CSC compartment features a specific and phenotypically defined cell...
We consider an ecosystem in which spiders may be transported by the wind from vineyards into the surrounding woods and vice versa. The model takes into account this tranport phenomenon without building space explicitly into the governing equations. The equilibria of the dynamical system are analyzed together with their stability, showing that bifurcations may occur. Then the effects of indiscriminated spraying to keep pests under control is also investigated via suitable simulations.
Tuberculosis (TB) is the leading cause of death among individuals infected with the hepatitis B virus (HBV). The study of the joint dynamics of HBV and TB present formidable mathematical challenges due to the fact that the models of transmission are quite distinct. We formulate and analyze a deterministic mathematical model which incorporates of the co-dynamics of hepatitis B and tuberculosis. Two sub-models, namely: HBV-only and TB-only sub-models...
We propose a new framework for the study of continuous time dynamical systems on networks. We view such dynamical systems as collections of interacting control systems. We show that a class of maps between graphs called graph fibrations give rise to maps between dynamical systems on networks. This allows us to produce conjugacy between dynamical systems out of combinatorial data. In particular we show that surjective graph fibrations lead to synchrony subspaces in networks. The injective graph fibrations,...
We derive the modulation equations (Whitham equations) for the Camassa-Holm (CH) equation. We show that the modulation equations are hyperbolic and admit a bi-Hamiltonian structure. Furthermore they are connected by a reciprocal transformation to the modulation equations of the first negative flow of the Korteweg de Vries (KdV) equation. The reciprocal transformation is generated by the Casimir of the second Poisson bracket of the KdV averaged flow. We show that the geometry...
A multiplicative structure in the cohomological version of Conley index is described following a joint paper by the author with K. Gęba and W. Uss. In the case of equivariant flows we apply a normalization procedure known from equivariant degree theory and we propose a new continuation invariant. The theory is applied then to obtain a mountain pass type theorem. Another illustrative application is a result on multiple bifurcations for some elliptic PDE.
A holomorphic 1-form on a compact Riemann surface S naturally defines a flat metric on S with cone-type singularities. We present the following surprising phenomenon: having found a geodesic segment (saddle connection) joining a pair of conical points one can find with a nonzero probability another saddle connection on S having the same direction and the same length as the initial one. A similar phenomenon is valid for the families of parallel closed geodesics. We give a complete description of...
We consider germs of one-parameter generic families of resonant analytic diffeomorphims and we give a complete modulus of analytic classification by means of the unfolding of the Écalle modulus. We describe the parametric resurgence phenomenon. We apply this to give a complete modulus of orbital analytic classification for the unfolding of a generic resonant saddle of a 2-dimensional vector field by means of the unfolding of its holonomy map. Here again the modulus is an unfolding of the Martinet-Ramis...
We give a complete topological classification of germs of holomorphic foliations in the plane under rather generic conditions. The key point is the introduction of a new topological invariant called monodromy representation. This monodromy contains all the relevant dynamical information, in particular the projective holonomy representations whose topological invariance was conjectured in the eighties by Cerveau and Sad and is proved here under mild hypotheses.