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We consider the discrete survival red blood cells model (*) , where δₙ and Pₙ are positive sequences. In the autonomous case we show that (*) has a unique positive steady state N*, we establish some sufficient conditions for oscillation of all positive solutions about N*, and when k = 1 we give a sufficient condition for N* to be globally asymptotically stable. In the nonatonomous case, assuming that there exists a positive solution Nₙ*, we present necessary and sufficient conditions for oscillation...
A mathematical model for a problem of blood perfusion in a living tissue through a system of parallel capillaries is studied. Oxygen is assumed to be transported in two forms: freely diffusing and bounded (to erytrocytes in blood, to myoglobin in tissue). Existence of a weak solution is proved and a homogensation procedure is carried out in the case of randomly distribuited capillaries.
Parameter estimation in non linear mixed effects models requires a large number of evaluations of the model to study. For ordinary differential equations, the overall computation time remains reasonable. However when the model itself is complex (for instance when it is a set of partial differential equations) it may be time consuming to evaluate it for a single set of parameters. The procedures of population parametrization (for instance using SAEM algorithms) are then very long and in some cases...
Fermentation processes as objects of modelling and high-quality control are characterized with interdependence and time-varying of process variables that lead to non-linear models with a very complex structure. This is why the conventional optimization methods cannot lead to a satisfied solution. As an alternative, genetic algorithms, like the stochastic global optimization method, can be applied to overcome these limitations. The application of genetic algorithms is a precondition for robustness...
Non-linear mixed models defined by stochastic differential equations (SDEs) are considered: the parameters of the diffusion process are random variables and vary among the individuals. A maximum likelihood estimation method based on the Stochastic Approximation EM algorithm, is proposed. This estimation method uses the Euler-Maruyama approximation of the diffusion, achieved using latent auxiliary data introduced to complete the diffusion process between each pair of measurement instants. A tuned...
Various particle methods are widely used to model dynamics of complex media. In this work molecular dynamics and dissipative particles dynamics are applied to model blood flows composed of plasma and erythrocytes. The properties of the homogeneous particle fluid are studied. Capillary flows with erythrocytes are investigated.
Recent technological advances including brain imaging (higher resolution in space and time), miniaturization of integrated circuits (nanotechnologies), and acceleration of computation speed (Moore’s Law), combined with interpenetration between neuroscience, mathematics, and physics have led to the development of more biologically plausible computational models and novel therapeutic strategies. Today, mathematical models of irreversible medical conditions...
We study a reaction-diffusion equation with an integral term describing nonlocal consumption of resources in population dynamics. We show that a homogeneous equilibrium can lose its stability resulting in appearance of stationary spatial structures. They can be related to the emergence of biological species due to the intra-specific competition and random mutations. Various types of travelling waves are observed.
We study pattern-forming instabilities in reaction-advection-diffusion systems. We develop an approach based on Lyapunov-Bloch exponents to figure out the impact of a spatially periodic mixing flow on the stability of a spatially homogeneous state. We deal with the flows periodic in space that may have arbitrary time dependence. We propose a discrete in time model, where reaction, advection, and diffusion act as successive operators, and show that...
We present a three species model describing the degradation of substrate by two competing populations of microorganisms in a marine sediment. Considering diffusion to be the main transport process, we obtain a reaction diffusion system (RDS) which we study in terms of spontaneous pattern formation. We find that the conditions for patterns to evolve are likely to be fulfilled in the sediment. Additionally, we present simulations that are consistent with experimental data from the literature. We...
We study the coexistence of multiple periodic solutions for an analogue of the integrate-and-fire neuron model of two-neuron recurrent inhibitory loops with delayed feedback, which incorporates the firing process and absolute refractory period. Upon receiving an excitatory signal from the excitatory neuron, the inhibitory neuron emits a spike with a pattern-related delay, in addition to the synaptic delay. We present a theoretical framework to view...
Parameterization of zooplankton functional response is crucial for constructing plankton models. Theoretical studies predict enhancing of system stability in case the response is of sigmoid type. Experiments on feeding in laboratories tell us in favor of non-sigmoid types for most herbivorous zooplankton species. However, recent field observations show that the overall functional response of zooplankton in the whole euphotic zone can exhibit a sigmoid behavior even when the response for the same...