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Generalized differential equations in the space of regulated functions (boundary value problems and controllability)

Milan Tvrdý (1991)

Mathematica Bohemica

Boundary value problems for generalized linear differential equations and the corresponding controllability problems are dealt with. The adjoint problems are introduced in such a way that the usual duality theorems are valid. As a special case the interface boundary value problems are included. In contrast to the earlier papers by the author the right-hand side of the generalized differential equations as well as the solutions of this equation can be in general regulated functions (not necessarily...

Global stability of steady solutions for a model in virus dynamics

Hermano Frid, Pierre-Emmanuel Jabin, Benoît Perthame (2003)

ESAIM: Mathematical Modelling and Numerical Analysis - Modélisation Mathématique et Analyse Numérique

We consider a simple model for the immune system in which virus are able to undergo mutations and are in competition with leukocytes. These mutations are related to several other concepts which have been proposed in the literature like those of shape or of virulence – a continuous notion. For a given species, the system admits a globally attractive critical point. We prove that mutations do not affect this picture for small perturbations and under strong structural assumptions. Based on numerical...

Global Stability of Steady Solutions for a Model in Virus Dynamics

Hermano Frid, Pierre-Emmanuel Jabin, Benoît Perthame (2010)

ESAIM: Mathematical Modelling and Numerical Analysis

We consider a simple model for the immune system in which virus are able to undergo mutations and are in competition with leukocytes. These mutations are related to several other concepts which have been proposed in the literature like those of shape or of virulence – a continuous notion. For a given species, the system admits a globally attractive critical point. We prove that mutations do not affect this picture for small perturbations and under strong structural assumptions. Based on numerical...

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