Calculating summary measures of unimodal response curves by means of nonlinear regression models.
The problem of assessing the reliability of clusters patients identified by clustering algorithms is crucial to estimate the significance of subclasses of diseases detectable at bio-molecular level, and more in general to support bio-medical discovery of patterns in gene expression data. In this paper we present an experimental analysis of the reliability of clusters discovered in lung tumor patients using DNA microarray data. In particular we investigate if subclasses of lung adenocarcinoma...
Many image segmentation algorithms have been proposed to partition an image into foreground regions of interest and background regions to be ignored. These algorithms use pixel intensities to partition the image, so it should be good practice to choose an appropriate background color as different as possible from the foreground one. In the case of a unique digitizing operation the user can make the choice of background color by himself in order to obtain a good result in the segmentation process,...
AMS Subj. Classification: 62P10, 62H30, 68T01This study examines different approaches of binary classification applied to the prob- lem of making distinction between former and current smokers. Prediction is based on data collected in national survey performed by the National center for health statistics of America in 2000. The process consists of two essential parts. The first one determines which attributes are relevant to smokers status, by using methods like basic genetic algorithm and different evaluation...
Compartmentalization is a general principle in biological systems which is observable on all size scales, ranging from organelles inside of cells, cells in histology, and up to the level of groups, herds, swarms, meta-populations, and populations. Compartmental models are often used to model such phenomena, but such models can be both highly nonlinear and difficult to work with.Fortunately, there are many significant biological systems that are amenable to linear compartmental models which are often...
La cartografía de enfermedades infecciosas en periodos sucesivos plantea la necesidad de su extensión al caso dinámico. En este trabajo proponemos la concatenación temporal de modelos auto-regresivos espaciales para abordar el análisis de mortalidad por meningitis en España en el período 1950-1990 con datos agregados a nivel provincial. Para la estimación v selección del modelo usamos técnicas basadas en la función de verosimilitud.
Costs or benefits which accumulate for individuals over time are of interest in many life history processes. Familiar examples include costs of health care for persons with chronic medical conditions, the payments to insured persons during periods of disability, and quality of life which is sometimes used in the evaluation of treatments in terminally ill patients. For convenience, here we use the term costs to refer to cost or other cumulative measures. Two important scenarios are (i) where costs...