La statistica nelle prove cliniche
Si descrivono le attività e le responsabilità dello statistico professionale nella conduzione di una prova clinica in una industria farmaceutica o in un ente di ricerca.
L'analyse séquentielle exhaustive. Application en médecine
L'Hospital type rules for oscillation, with applications.
Likelihood for interval-censored observations from multi-state models.
We consider the mixed dicrete-continuous pattern of observation in a multi-state model; this is a classical pattern because very often clinical status is assessed at discrete visit times while time of death is observed exactly. The likelihood can easily be written heuristically for such models. However a formal proof is not easy in such observational patterns. We give a rigorous derivation al the likelihood for the illness-death model based on applying Jacod´s formula to an observed bivariate counting...
Linking population genetics to phylogenetics
Population geneticists study the variability of gene sequences within a species, whereas phylogeneticists compare gene sequences between species and usually have only one representative sequence per species. Stochastic models in population genetics are used to determine probability distributions for gene frequencies and to predict the probability that a new mutation will become fixed in a population. Stochastic models in phylogenetics describe the substitution process in the single sequence that...
Locally weighted neural networks for an analysis of the biosensor response
This paper presents a semi-global mathematical model for an analysis of a signal of amperometric biosensors. Artificial neural networks were applied to an analysis of the biosensor response to multi-component mixtures. A large amount of the learning and test data was synthesized using computer simulation of the biosensor response. The biosensor signal was analyzed with respect to the concentration of each component of the mixture. The paradigm of locally weighted linear regression was used for retraining...