A mathematical model of the microalgal growth under various light regimes is required for the optimization of design parameters and operating conditions in a photobioreactor. As its modelling framework, bilinear system with single input is chosen in this paper. The earlier theoretical results on bilinear systems are adapted and applied to the special class of the so-called intermittent controls which are characterized by rapid switching of light and dark cycles. Based on such approach, the following...

The well-known bottleneck of systems pharmacology, i. e., systems biology applied to pharmacology, refers to the model parameters determination from experimentally measured datasets. This paper represents the development of our earlier studies devoted to inverse (ill-posed) problems of model parameters identification. The key feature of this research is the introduction of control (or periodic forcing by an input signal being a drug intake) of the nonlinear model of drug-induced enzyme production...

In this paper, we will consider blowup solutions to the so called Keller-Segel system and its simplified form. The Keller-Segel system was introduced to describe how cellular slime molds aggregate, owing to the motion of the cells toward a higher concentration of a chemical substance produced by themselves. We will describe a common conjecture in connection with blowup solutions to the Keller-Segel system, and some results for solutions to simplified versions of the Keller-Segel system, giving the...

A class of nonlinear viscous transport equations describing aggregation phenomena in biology is considered. General conditions on an interaction potential are obtained which lead either to the existence or to the nonexistence of global-in-time solutions.

Since the release of the Bio 2010 report in 2003, significant emphasis has been placed on initiating changes in the way undergraduate biology and mathematics courses are taught and on creating new educational materials to facilitate those changes. Quantitative approaches, including mathematical models, are now considered critical for the education of the next generation of biologists. In response, mathematics departments across the country have initiated changes to their introductory calculus sequence,...

We review the optimal design of an arterial bypass graft following either a (i) boundary optimal control approach, or a (ii) shape optimization formulation. The main focus is quantifying and treating the uncertainty in the residual flow when the hosting artery is not completely occluded, for which the worst-case in terms of recirculation effects is inferred to correspond to a strong orifice flow through near-complete occlusion.A worst-case optimal control approach is applied to the steady Navier-Stokes...

This paper is concerned with the two-species chemotaxis-Navier–Stokes system with Lotka–Volterra competitive kinetics $$\begin{array}{c}\hfill \left\{\begin{array}{cc}{\left(1\right)}_t+u·1=𝔻1-{\chi }_1·\left(1c\right)+{\mu }_{1}1(1-1-a_{1}2)\hfill & \text{in}\times (0,\infty ),\hfill \\ {\left(2\right)}_t+u·2=𝔻2-{\chi }_2·\left(2c\right)+{\mu }_{2}2(1-a_{2}1-2)\hfill & \text{in}\times (0,\infty ),\hfill \\ c_t+u·c=𝔻c-(\alpha 1+\beta 2)c\hfill & \text{in}\times (0,\infty ),\hfill \\ u_t+(u·)u=𝔻u+\nabla P+(\gamma 1+2)\Phi ,·u=0\hfill & \text{in}\times (0,\infty )\hfill \end{array}\right.\end{array}$$ under homogeneous Neumann boundary conditions and initial conditions, where is a bounded domain in R3 with smooth boundary. Recently, in the 2-dimensional setting, global existence and stabilization of classical solutions to the above system were first established. However, the 3-dimensional case has not been studied: Because of difficulties in the Navier–Stokes system, we can...