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Hematologic Disorders and Bone Marrow–Peripheral Blood Dynamics

E. Afenya, S. Mundle (2010)

Mathematical Modelling of Natural Phenomena

Hematologic disorders such as the myelodysplastic syndromes (MDS) are discussed. The lingering controversies related to various diseases are highlighted. A simple biomathematical model of bone marrow - peripheral blood dynamics in the normal state is proposed and used to investigate cell behavior in normal hematopoiesis from a mathematical viewpoint. Analysis of the steady state and properties of the model are used to make postulations about the...

Herbivore harvesting and alternative steady states in coral reefs

Ikbal Hossein Sarkar, Joydeb Bhattacharyya, Samares Pal (2021)

Applications of Mathematics

Coral reefs can undergo relatively rapid changes in the dominant biota, a phenomenon referred to as phase shift. Degradation of coral reefs is often associated with changes in community structure towards a macroalgae-dominated reef ecosystem due to the reduction in herbivory caused by overfishing. We investigate the coral-macroalgal phase shift due to the effects of harvesting of herbivorous reef fish by means of a continuous time model in the food chain. Conditions for local asymptotic stability...

High Resolution Tracking of Cell Membrane Dynamics in Moving Cells: an Electrifying Approach

R.A. Tyson, D.B.A. Epstein, K.I. Anderson, T. Bretschneider (2010)

Mathematical Modelling of Natural Phenomena

Cell motility is an integral part of a diverse set of biological processes. The quest for mathematical models of cell motility has prompted the development of automated approaches for gathering quantitative data on cell morphology, and the distribution of molecular players involved in cell motility. Here we review recent approaches for quantifying cell motility, including automated cell segmentation and tracking. Secondly, we present our own novel...

High-order WENO scheme for polymerization-type equations*

Pierre Gabriel, Léon Matar Tine (2010)

ESAIM: Proceedings

Polymerization of proteins is a biochemical process involved in different diseases. Mathematically, it is generally modeled by aggregation-fragmentation-type equations. In this paper we consider a general polymerization model and propose a high-order numerical scheme to investigate the behavior of the solution. An important property of the equation is the mass conservation. The WENO scheme is built to preserve the total mass of proteins along time....

Homoclinic orbits in a two-patch predator-prey model with Preisach hysteresis operator

Alexander Pimenov, Dmitrii Rachinskii (2014)

Mathematica Bohemica

Systems of operator-differential equations with hysteresis operators can have unstable equilibrium points with an open basin of attraction. Such equilibria can have homoclinic orbits attached to them, and these orbits are robust. In this paper a population dynamics model with hysteretic response of the prey to variations of the predator is introduced. In this model the prey moves between two patches, and the derivative of the Preisach operator is used to describe the hysteretic flow between the...

Homogeneous Systems with a Quiescent Phase

K. P. Hadeler (2008)

Mathematical Modelling of Natural Phenomena

Recently the effect of a quiescent phase (or dormant/resting phase in applications) on the dynamics of a system of differential equations has been investigated, in particular with respect to stability properties of stationary points. It has been shown that there is a general phenomenon of stabilization against oscillations which can be cast in rigorous form. Here we investigate, for homogeneous systems, the effect of a quiescent phase, and more generally, a phase with slower dynamics. We show that...

Homogenization of a carcinogenesis model with different scalings with the homogenization parameter

Isabell Graf, Malte A. Peter (2014)

Mathematica Bohemica

In the context of periodic homogenization based on two-scale convergence, we homogenize a linear system of four coupled reaction-diffusion equations, two of which are defined on a manifold. The system describes the most important subprocesses modeling the carcinogenesis of a human cell caused by Benzo-[a]-pyrene molecules. These molecules are activated to carcinogens in a series of chemical reactions at the surface of the endoplasmic reticulum, which constitutes a fine structure inside the cell....

Hopf Bifurcation Analysis of Pathogen-Immune Interaction Dynamics With Delay Kernel

M. Neamţu, L. Buliga, F. R. Horhat, D. Opriş (2010)

Mathematical Modelling of Natural Phenomena

The aim of this paper is to study the steady states of the mathematical models with delay kernels which describe pathogen-immune dynamics of infectious diseases. In the study of mathematical models of infectious diseases it is important to predict whether the infection disappears or the pathogens persist. The delay kernel is described by the memory function that reflects the influence of the past density of pathogen in the blood and it is given by a nonnegative bounded and normated function k defined...

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