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Robust numerical approximation of coupled Stokes' and Darcy's flows applied to vascular hemodynamics and biochemical transport*

Carlo D'Angelo, Paolo Zunino (2011)

ESAIM: Mathematical Modelling and Numerical Analysis

The fully coupled description of blood flow and mass transport in blood vessels requires extremely robust numerical methods. In order to handle the heterogeneous coupling between blood flow and plasma filtration, addressed by means of Navier-Stokes and Darcy's equations, we need to develop a numerical scheme capable to deal with extremely variable parameters, such as the blood viscosity and Darcy's permeability of the arterial walls. In this paper, we describe a finite element method for...

Robust numerical approximation of coupled Stokes' and Darcy's flows applied to vascular hemodynamics and biochemical transport*

Carlo D'Angelo, Paolo Zunino (2011)

ESAIM: Mathematical Modelling and Numerical Analysis

The fully coupled description of blood flow and mass transport in blood vessels requires extremely robust numerical methods. In order to handle the heterogeneous coupling between blood flow and plasma filtration, addressed by means of Navier-Stokes and Darcy's equations, we need to develop a numerical scheme capable to deal with extremely variable parameters, such as the blood viscosity and Darcy's permeability of the arterial walls. In this paper, we describe a finite element method for...

Segregation of Flowing Blood: Mathematical Description

A. Tokarev, G. Panasenko, F. Ataullakhanov (2011)

Mathematical Modelling of Natural Phenomena

Blood rheology is completely determined by its major corpuscles which are erythrocytes, or red blood cells (RBCs). That is why understanding and correct mathematical description of RBCs behavior in blood is a critical step in modelling the blood dynamics. Various phenomena provided by RBCs such as aggregation, deformation, shear-induced diffusion and non-uniform radial distribution affect the passage of blood through the vessels. Hence, they have...

Spatial Dynamics of Contact-Activated Fibrin Clot Formation in vitro and in silico in Haemophilia B: Effects of Severity and Ahemphil B Treatment

A. A. Tokarev, Yu. V. Krasotkina, M. V. Ovanesov, M. A. Panteleev, M. A. Azhigirova, V. A. Volpert, F. I. Ataullakhanov, A. A. Butilin (2010)

Mathematical Modelling of Natural Phenomena

Spatial dynamics of fibrin clot formation in non-stirred system activated by glass surface was studied as a function of FIX activity. Haemophilia B plasma was obtained from untreated patients with different levels of FIX deficiency and from severe haemophilia B patient treated with FIX concentrate (Ahemphil B) during its clearance with half-life t1/2=12 hours. As reported previously (Ataullakhanov et al. Biochim Biophys Acta 1998; 1425: 453-468), clot growth in space showed two distinct phases:...

Time domain computational modelling of 1D arterial networks in monochorionic placentas

Victoria E. Franke, Kim H. Parker, Ling Y. Wee, Nicholas M. Fisk, Spencer J. Sherwin (2003)

ESAIM: Mathematical Modelling and Numerical Analysis - Modélisation Mathématique et Analyse Numérique

In this paper we outline the hyperbolic system of governing equations describing one-dimensional blood flow in arterial networks. This system is numerically discretised using a discontinuous Galerkin formulation with a spectral/ h p element spatial approximation. We apply the numerical model to arterial networks in the placenta. Starting with a single placenta we investigate the velocity waveform in the umbilical artery and its relationship with the distal bifurcation geometry and the terminal resistance....

Time domain computational modelling of 1D arterial networks in monochorionic placentas

Victoria E. Franke, Kim H. Parker, Ling Y. Wee, Nicholas M. Fisk, Spencer J. Sherwin (2010)

ESAIM: Mathematical Modelling and Numerical Analysis

In this paper we outline the hyperbolic system of governing equations describing one-dimensional blood flow in arterial networks. This system is numerically discretised using a discontinuous Galerkin formulation with a spectral/hp element spatial approximation. We apply the numerical model to arterial networks in the placenta. Starting with a single placenta we investigate the velocity waveform in the umbilical artery and its relationship with the distal bifurcation geometry and the terminal resistance....

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