Mathematical and computer modelling of mechanisms regulating blood flow at microcirculation level [Abstract of thesis]
Mathematical and numerical modeling of early atherosclerotic lesions***
This article is devoted to the construction of a mathematical model describing the early formation of atherosclerotic lesions. The early stage of atherosclerosis is an inflammatory process that starts with the penetration of low density lipoproteins in the intima and with their oxidation. This phenomenon is closely linked to the local blood flow dynamics. Extending a previous work [5] that was mainly restricted to a one-dimensional setting, we couple...
Mathematical model of airflow in the lungs of children. I: Effects of tumor sizes and locations.
Mathematical model of airflow in the lungs of children II: Effects of ventilatory parameters.
Mathematical modelling of profiled haemodialysis: A simplified approach.
Medical image – based computational model of pulsatile flow in saccular aneurisms
Saccular aneurisms, swelling of a blood vessel, are investigated in order (i) to estimate the development risk of the wall lesion, before and after intravascular treatment, assuming that the pressure is the major factor, and (ii) to better plan medical interventions. Numerical simulations, using the finite element method, are performed in three-dimensional aneurisms. Computational meshes are derived from medical imaging data to take into account both between-subject and within-subject anatomical...
Medical image – based computational model of pulsatile flow in saccular aneurisms
Saccular aneurisms, swelling of a blood vessel, are investigated in order (i) to estimate the development risk of the wall lesion, before and after intravascular treatment, assuming that the pressure is the major factor, and (ii) to better plan medical interventions. Numerical simulations, using the finite element method, are performed in three-dimensional aneurisms. Computational meshes are derived from medical imaging data to take into account both between-subject and within-subject anatomical...
Modeling of the oxygen transfer in the respiratory process
In this article, we propose an integrated model for oxygen transfer into the blood, coupled with a lumped mechanical model for the ventilation process. Objectives. We aim at investigating oxygen transfer into the blood at rest or exercise. The first task consists in describing nonlinear effects of the oxygen transfer under normal conditions. We also include the possible diffusion limitation in oxygen transfer observed in extreme regimes involving parameters such as alveolar and venous blood oxygen...
Modeling the Dynamics of the Cardiovascular-respiratory System (CVRS) in Humans, a Survey
In this paper we give a survey on modeling efforts concerning the CVRS. The material we discuss is organized in accordance with modeling goals and stresses control and transport issues. We also address basic modeling approaches and discuss some of the challenges for mathematical modeling methodologies in the context of parameter estimation and model validation.
Modelling, analysis and calculation of cerebral hemodynamics.
Modelling the Impact of Pericyte Migration and Coverage of Vessels on the Efficacy of Vascular Disrupting Agents
Over the past decade or so, there have been a large number of modelling approaches aimed at elucidating the most important mechanisms affecting the formation of new capillaries from parent blood vessels — a process known as angiogenesis. Most studies have focussed upon the way in which capillary sprouts are initiated and migrate in response to diffusible chemical stimuli supplied by hypoxic stromal cells and leukocytes in the contexts of solid tumour...
Multichannel blind deconvolution using the stochastic calculus for the estimation of the central arterial pressure.