Fluid-retention side-effects of the chemotherapy-supportive treatment interleukin-11: mathematical modelling of putative underlying mechanisms.
Free boundary problems arising in tumor models
We consider several simple models of tumor growth, described by systems of PDEs, and describe results on existence of solutions and on their asymptotic behavior. The boundary of the tumor region is a free boundary. In §1 the model assumes three types of cells, proliferating, quiescent and necrotic, and the corresponding PDE system consists of elliptic, parabolic and hyperbolic equations. The model in §2 assumes that the tumor has only proliferating cells. Finally in §3 we consider a model for treatment...
Free Boundary Problems Associated with Multiscale Tumor Models
The present paper introduces a tumor model with two time scales, the time t during which the tumor grows and the cycle time of individual cells. The model also includes the effects of gene mutations on the population density of the tumor cells. The model is formulated as a free boundary problem for a coupled system of elliptic, parabolic and hyperbolic equations within the tumor region, with nonlinear and nonlocal terms. Existence and uniqueness theorems are proved, and properties of the free boundary...