Necrosis and apoptosis: Distinct cell loss mechanisms in a mathematical model of avascular tumour growth.
Negative control of cell proliferation. Growth arrest versus apoptosis. Role of GBP.
Neural network based identification of hysteresis in human meridian systems
Developing a model based digital human meridian system is one of the interesting ways of understanding and improving acupuncture treatment, safety analysis for acupuncture operation, doctor training, or treatment scheme evaluation. In accomplishing this task, how to construct a proper model to describe the behavior of human meridian systems is one of the very important issues. From experiments, it has been found that the hysteresis phenomenon occurs in the relations between stimulation input and...
New Computational Tools for Modeling Chronic Myelogenous Leukemia
In this paper, we consider a system of nonlinear delay-differential equations (DDEs) which models the dynamics of the interaction between chronic myelogenous leukemia (CML), imatinib, and the anti-leukemia immune response. Because of the chaotic nature of the dynamics and the sparse nature of experimental data, we look for ways to use computation to analyze the model without employing direct numerical simulation. In particular, we develop several tools using Lyapunov-Krasovskii analysis that allow...
New dimensions in Gompertzian growth.
New Resolution Strategy for Multi-scale Reaction Waves using Time Operator Splitting and Space Adaptive Multiresolution: Application to Human Ischemic Stroke*
We tackle the numerical simulation of reaction-diffusion equations modeling multi-scale reaction waves. This type of problems induces peculiar difficulties and potentially large stiffness which stem from the broad spectrum of temporal scales in the nonlinear chemical source term as well as from the presence of large spatial gradients in the reactive fronts, spatially very localized. A new resolution strategy was recently introduced ? that combines...
Noninvasive monitoring of hepatic damage from hepatitis C virus infection.
Non-linear analysis approach of maternal heart rate patterns in normal pre-eclamptic pregnancies.
Nonlinear filtering of oscillatory measurements in cardiovascular applications.
Nonlinear reaction-diffusion models of self-organization and deterministic chaos: theory and possible applications to description of electrical cardiac activity and cardiovascular circulation.
Nonparametric bivariate estimation for successive survival times.
Several aspects of the analysis of two successive survival times are considered. All the analyses take into account the dependent censoring on the second time induced by the first. Three nonparametric methods are described, implemented and applied to the data coming from a multicentre clinical trial for HIV-infected patients. Visser's and Wang and Wells methods propose an estimator for the bivariate survival function while Gómez and Serrat's method presents a conditional approach for the second...
Nuclei segmentation for computer-aided diagnosis of breast cancer
Numerical simulation of blood flows through a porous interface
We propose a model for a medical device, called a stent, designed for the treatment of cerebral aneurysms. The stent consists of a grid, immersed in the blood flow and located at the inlet of the aneurysm. It aims at promoting a clot within the aneurysm. The blood flow is modelled by the incompressible Navier-Stokes equations and the stent by a dissipative surface term. We propose a stabilized finite element method for this model and we analyse its convergence in the case of the Stokes...
Numerical simulation of surface acoustic wave actuated cell sorting
We consider the mathematical modeling and numerical simulation of high throughput sorting of two different types of biological cells (type I and type II) by a biomedical micro-electro-mechanical system (BioMEMS) whose operating behavior relies on surface acoustic wave (SAW) manipulated fluid flow in a microchannel. The BioMEMS consists of a separation channel with three inflow channels for injection of the carrier fluid and the cells, two outflow channels for separation, and an interdigital transducer...
Numerical simulations of effects of multiple neurotransmission on intestinal propulsion of a non-deformable bolus.
Numerical simulations of fractionated electrograms and pathological cardiac action potential.
Numerical solutions for a model of tissue invasion and migration of tumour cells.
Numerical study of the stopping of aura during migraine
This work is devoted to the study of migraine with aura in the human brain. Following [6], we class migraine as a propagation of a wave of depolarization through the cells. The mathematical model used, based on a reaction-diffusion equation, is briefly presented. The equation is considered in a duct containing a bend, in order to model one of the numerous circumvolutions of the brain. For a wide set of parameters, one can establish the existence...