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Rapid Emergence of Co-colonization with Community-acquired and Hospital-Acquired Methicillin-Resistant Staphylococcus aureus Strains in the Hospital Setting

E. M. C. D’Agata, G. F. Webb, J. Pressley (2010)

Mathematical Modelling of Natural Phenomena

Background: Community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA), a novel strain of MRSA, has recently emerged and rapidly spread in the community. Invasion into the hospital setting with replacement of the hospital-acquired MRSA (HA-MRSA) has also been documented. Co-colonization with both CA-MRSA and HA-MRSA would have important clinical implications given differences in antimicrobial susceptibility profiles and the potential...

Reaction-Difusion Model of Early Carcinogenesis: The Effects of Influx of Mutated Cells

Anna Marciniak-Czochra, Marek Kimmel (2008)

Mathematical Modelling of Natural Phenomena

In this paper we explore a new model of field carcinogenesis, inspired by lung cancer precursor lesions, which includes dynamics of a spatially distributed population of pre-cancerous cells c(t, x), constantly supplied by an influx μ of mutated normal cells. Cell proliferation is controlled by growth factor molecules bound to cells, b(t, x). Free growth factor molecules g(t, x) are produced by precancerous cells and may diffuse before they become bound to other cells. The purpose of modelling is...

Recognition of atherosclerotic plaques and their extended dimensioning with computerized tomography angiography imaging

Tomasz Markiewicz, Mirosław Dziekiewicz, Marek Maruszyński, Romana Bogusławska-Walecka, Wojciech Kozłowski (2014)

International Journal of Applied Mathematics and Computer Science

In this paper the authors raise the issue of automatic discrimination of atherosclerotic plaques within an artery lumen based on numerical and statistical thresholding of Computerized Tomography Angiographic (CTA) images and their advanced dimensioning as a support for preoperative vessel assessment. For the study, a set of tomograms of the aorta, as well as the ilio-femoral and femoral arteries were examined. In each case a sequence of about 130-480 images of the artery cutoff planes were analyzed...

Regulation of p53 by siRNA in radiation treated cells: Simulation studies

Krzysztof Puszyński, Roman Jaksik, Andrzej Świerniak (2012)

International Journal of Applied Mathematics and Computer Science

Ionizing radiation activates a large variety of intracellular mechanisms responsible for maintaining appropriate cell functionality or activation of apoptosis which eliminates damaged cells from the population. The mechanism of such induced cellular death is widely used in radiotherapy in order to eliminate cancer cells, although in some cases it is highly limited by increased cellular radio-resistance due to aberrations in molecular regulation mechanisms of malignant cells. Despite the positive...

Robust numerical approximation of coupled Stokes' and Darcy's flows applied to vascular hemodynamics and biochemical transport*

Carlo D'Angelo, Paolo Zunino (2011)

ESAIM: Mathematical Modelling and Numerical Analysis

The fully coupled description of blood flow and mass transport in blood vessels requires extremely robust numerical methods. In order to handle the heterogeneous coupling between blood flow and plasma filtration, addressed by means of Navier-Stokes and Darcy's equations, we need to develop a numerical scheme capable to deal with extremely variable parameters, such as the blood viscosity and Darcy's permeability of the arterial walls. In this paper, we describe a finite element method for...

Robust numerical approximation of coupled Stokes' and Darcy's flows applied to vascular hemodynamics and biochemical transport*

Carlo D'Angelo, Paolo Zunino (2011)

ESAIM: Mathematical Modelling and Numerical Analysis

The fully coupled description of blood flow and mass transport in blood vessels requires extremely robust numerical methods. In order to handle the heterogeneous coupling between blood flow and plasma filtration, addressed by means of Navier-Stokes and Darcy's equations, we need to develop a numerical scheme capable to deal with extremely variable parameters, such as the blood viscosity and Darcy's permeability of the arterial walls. In this paper, we describe a finite element method for...

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