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Identifiability and estimation of pharmacokinetic parameters for the ligands of the macrophage mannose receptor

Nathalie Verdiere, Lilianne Denis-Vidal, Ghislaine Joly-Blanchard, Dominique Domurado (2005)

International Journal of Applied Mathematics and Computer Science

The aim of this paper is numerical estimation of pharmacokinetic parameters of the ligands of the macrophage mannose receptor, without knowing it a priori the values of these parameters. However, it first requires a model identifiability analysis, which is done by applying an algorithm implemented in a symbolic computation language. It is shown that this step can lead to a direct numerical estimation algorithm. In this way, a first estimate is computed from noisy simulated observations without it...

Inequality-based approximation of matrix eigenvectors

András Kocsor, József Dombi, Imre Bálint (2002)

International Journal of Applied Mathematics and Computer Science

A novel procedure is given here for constructing non-negative functions with zero-valued global minima coinciding with eigenvectors of a general real matrix A. Some of these functions are distinct because all their local minima are also global, offering a new way of determining eigenpairs by local optimization. Apart from describing the framework of the method, the error bounds given separately for the approximation of eigenvectors and eigenvalues provide a deeper insight into the fundamentally...

Input constraints handling in an MPC/feedback linearization scheme

Jiamei Deng, Victor M. Becerra, Richard Stobart (2009)

International Journal of Applied Mathematics and Computer Science

The combination of model predictive control based on linear models (MPC) with feedback linearization (FL) has attracted interest for a number of years, giving rise to MPC+FL control schemes. An important advantage of such schemes is that feedback linearizable plants can be controlled with a linear predictive controller with a fixed model. Handling input constraints within such schemes is difficult since simple bound contraints on the input become state dependent because of the nonlinear transformation...

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