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This paper addresses a Three-Dimensional Loading Capacitated Vehicle Routing Problem
(3L-CVRP) which combines a three-dimensional loading problem and vehicle routing problem
in distribution logistics. The problem requires the combinatorial optimization of a
feasible loading solution and a successive routing of vehicles to satisfy client demands,
where all vehicles must start and terminate at a central depot. In spite of its clear
practical significance...
This paper addresses a Three-Dimensional Loading Capacitated Vehicle Routing Problem
(3L-CVRP) which combines a three-dimensional loading problem and vehicle routing problem
in distribution logistics. The problem requires the combinatorial optimization of a
feasible loading solution and a successive routing of vehicles to satisfy client demands,
where all vehicles must start and terminate at a central depot. In spite of its clear
practical significance...
The invasive capability is fundamental in determining the malignancy of a solid tumor.
Revealing biomedical strategies that are able to partially decrease cancer invasiveness is
therefore an important approach in the treatment of the disease and has given rise to
multiple in vitro and in silico models. We here develop
a hybrid computational framework, whose aim is to characterize the effects of the
different cellular and subcellular mechanisms involved...
Maintaining liquid asset portfolios involves a high carry cost and is mandatory by law for most financial institutions. Taking this into account a financial institution's aim is to manage a liquid asset portfolio in an “optimal” way, such that it keeps the minimum required liquid assets to comply with regulations. In this paper we propose a multi-stage dynamic stochastic programming model for liquid asset portfolio management. The model allows for portfolio rebalancing decisions over a multi-period...
The question, how does an organism maintain balance? provides a unifying theme to
introduce undergraduate students to the use of mathematics and modeling techniques in
biological research. The availability of inexpensive high speed motion capture cameras
makes it possible to collect the precise and reliable data that facilitates the
development of relevant mathematical models. An in–house laboratory component ensures that
students have the opportunity...
A growing body of literature testifies to the importance of quantitative reasoning skills
in the 21st-century biology curriculum, and to the learning benefits associated with
active pedagogies. The process of modeling a biological system provides an approach that
integrates mathematical skills and higher-order thinking with existing course content
knowledge. We describe a general strategy for teaching model-building in an introductory
biology course,...
Compartmentalization is a general principle in biological systems which is observable on all size scales, ranging from organelles inside of cells, cells in histology, and up to the level of groups, herds, swarms, meta-populations, and populations. Compartmental models are often used to model such phenomena, but such models can be both highly nonlinear and difficult to work with.Fortunately, there are many significant biological systems that are amenable to linear compartmental models which are often...
Pharmacokinetics is an excellent way to introduce biomathematical modeling at the sophomore level. Students have the opportunity to develop a mathematical model of a biological phenomenon to which they all can relate. Exploring pharmacokinetics takes students through the necessary stages of mathematical modeling: determining the goals of the model, deciphering between the biological aspects to include in the model, defining the assumptions of the model, and finally, building, analyzing, using, and...
This article studies an equilibrium search problem when jobs provided by firms can be either unskilled or skilled and when workers differing in their education level can be either low-educated or high-educated. The structure proportion of jobs affects the equilibrium which indicates a threshold that can distinguish whether the equilibrium is separating or cross-skill. In addition, the cross-skill equilibrium solution implies the high-educated workers are more likely to obtain higher pay rates than...
One interesting example of a discrete mathematical model used in biology is a food web.
The first biology courses in high school and in college present the fundamental nature of
a food web, one that is understandable by students at all levels. But food webs as part of
a larger system are often not addressed. This paper presents materials that can be used in
undergraduate classes in biology (and mathematics) and provides students with the
opportunity...
HIV infection is multi-faceted and a multi-step process. The virus-induced pathogenic
mechanisms are manifold and mediated through a range of positive and negative feedback
regulations of immune and physiological processes engaged in virus-host interactions. The
fundamental questions towards understanding the pathogenesis of HIV infection are now
shifting to ‘dynamic’ categories: (i) why is the HIV-immune response equilibrium finally
disrupted? (ii)...
This paper demonstrates the development of a simple model of carbon flow during plant growth. The model was developed by six undergraduate students and their instructor as a project in a plant ecophysiology course. The paper describes the structure of the model including the equations that were used to implement it in Excel®, the plant growth experiments that were conducted to obtain information for parameterizing and testing the model, model performance, student responses to the modeling project,...
This article focuses on dynamic description of the collective pedestrian motion based on the kinetic model of Bhatnagar-Gross-Krook. The proposed mathematical model is based on a tendency of pedestrians to reach a state of equilibrium within a certain time of relaxation. An approximation of the Maxwellian function representing this equilibrium state is determined. A result of the existence and uniqueness of the discrete velocity model is demonstrated. Thus, the convergence of the solution to that...
This special issue of Mathematical Modelling of Natural Phenomena on biomathematics education shares the work of fifteen groups at as many different institutions that have developed beautiful biological applications of mathematics that are different in three ways from much of what is currently available. First, many of these selections utilize current research in biomathematics rather than the well-known textbook examples that are at least a half-century old. Second, the selections focus on modules...
Flow cytometric analysis using intracellular dyes such as CFSE is a powerful experimental
tool which can be used in conjunction with mathematical modeling to quantify the dynamic
behavior of a population of lymphocytes. In this survey we begin by providing an overview
of the mathematically relevant aspects of the data collection procedure. We then present
an overview of the large body of mathematical models, along with their assumptions and
uses,...
The discovery of nearly periodic vegetation patterns in arid and semi-arid regions
motivated numerous model studies in the past decade. Most studies have focused on
vegetation pattern formation, and on the response of vegetation patterns to gradients of
the limiting water resource. The reciprocal question, what resource modifications are
induced by vegetation pattern formation, which is essential to the understanding of
dryland landscapes, has hardly...
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