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We address the issue of parameter variations in POD approximations of time-dependent problems, without any specific restriction on the form of parameter dependence. Considering a parabolic model problem, we propose a POD construction strategy allowing us to obtain some a priori error estimates controlled by the POD remainder – in the construction procedure – and some parameter-wise interpolation errors for the model solutions. We provide a thorough numerical assessment of this strategy with the...
Vasculogenesis and angiogenesis are two different mechanisms for blood vessel formation. Angiogenesis occurs when new vessels sprout from pre-existing vasculature in response to external chemical stimuli. Vasculogenesis occurs via the reorganization of randomly distributed cells into a blood vessel network. Experimental models of vasculogenesis have suggested that the cells exert traction forces onto the extracellular matrix and that these forces may play an important role in the network forming...
Vasculogenesis and angiogenesis are two different mechanisms for blood
vessel formation. Angiogenesis occurs when new vessels sprout from
pre-existing vasculature in response to external chemical stimuli.
Vasculogenesis occurs via the reorganization of randomly distributed
cells into a blood vessel network. Experimental models
of vasculogenesis have suggested that the cells exert traction forces
onto the extracellular matrix and that these forces may play
an important role in the network forming...
This paper deals with modeling the passive
behavior of skeletal muscle tissue including
certain microvibrations at the cell level. Our
approach combines a continuum mechanics model
with large deformation and incompressibility at
the macroscale with chains of coupled
nonlinear oscillators.
The model verifies that an externally applied
vibration at the appropriate frequency is able to synchronize
microvibrations in skeletal muscle cells.
From the numerical analysis point of view,
one faces...
We propose a quasi-Newton algorithm for solving fluid-structure interaction problems. The basic idea of the method is to build an approximate tangent operator which is cost effective and which takes into account the so-called added mass effect. Various test cases show that the method allows a significant reduction of the computational effort compared to relaxed fixed point algorithms. We present 2D and 3D fluid-structure simulations performed either with a simple 1D structure model or with shells...
We propose a quasi-Newton algorithm for solving
fluid-structure interaction problems. The basic idea of the method is
to build an approximate tangent operator which is cost effective and
which takes into account the so-called added mass effect.
Various test cases show that the method allows a significant reduction
of the computational effort compared to relaxed fixed point
algorithms. We present 2D and 3D fluid-structure simulations performed
either with a simple 1D structure model or with...
A hyperelastic constitutive law, for use in anatomically accurate finite element models of living structures, is suggested for the passive and the active mechanical properties of incompressible biological tissues. This law considers the passive and active states as a same hyperelastic continuum medium, and uses an activation function in order to describe the whole contraction phase. The variational and the FE formulations are also presented, and the FE code has been validated and applied to describe...
A hyperelastic constitutive law, for use in anatomically accurate finite element models of
living structures, is suggested for the passive and the active mechanical properties of incompressible
biological tissues. This law considers the passive and active states as a same hyperelastic continuum
medium, and uses an activation function in order to describe the whole contraction phase.
The variational and the FE formulations are also presented, and the FE code has been validated
and applied to describe...
We derive a constitutive law for the myocardium from the description of both the geometrical arrangement of cardiomyocytes and their individual mechanical behaviour. We model a set of cardiomyocytes by a quasiperiodic discrete lattice of elastic bars interacting by means of moments. We work in a large displacement framework and we use a discrete homogenization technique. The macroscopic constitutive law is obtained through the resolution of a nonlinear self-equilibrum system of the discrete lattice...
We derive a constitutive law for the myocardium from the description of both the geometrical arrangement of
cardiomyocytes and their individual mechanical behaviour. We model a set of cardiomyocytes by a quasiperiodic discrete
lattice of elastic bars interacting by means of moments. We work in a large displacement framework and we use a discrete
homogenization technique. The macroscopic constitutive law is obtained through the resolution of a
nonlinear self-equilibrum system of the discrete lattice...
We consider a Canham − Helfrich − type variational problem defined over closed surfaces enclosing a fixed volume and having fixed surface area. The problem models the shape of multiphase biomembranes. It consists of minimizing the sum of the Canham − Helfrich energy, in which the bending rigidities and spontaneous curvatures are now phase-dependent, and a line tension penalization for the phase interfaces. By restricting attention to axisymmetric surfaces and phase distributions, we extend our previous...
When invading the tissue, malignant tumour cells (i.e. cancer cells) need to detach from
neighbouring cells, degrade the basement membrane, and migrate through the extracellular
matrix. These processes require loss of cell-cell adhesion and enhancement of cell-matrix
adhesion. In this paper we present a mathematical model of an intracellular pathway for
the interactions between a cancer cell and the extracellular matrix. Cancer cells use
similar...
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