On oscillatory solutions of second order differential systems
A pharmacodynamic model introduced earlier in the literature for in silico prediction of rifampicin-induced CYP3A4 enzyme production is described and some aspects of the involved curve-fitting based parameter estimation are discussed. Validation with our own laboratory data shows that the quality of the fit is particularly sensitive with respect to an unknown parameter representing the concentration of the nuclear receptor PXR (pregnane X receptor). A detailed analysis of the influence of that parameter...
In the paper the comparison method is used to prove the convergence of the Picard iterations, the Seidel iterations, as well as some modifications of these methods applied to approximate solution of systems of differential algebraic equations. The both linear and nonlinear comparison equations are emloyed.
We investigate the nonautonomous periodic system of ODE’s of the form , where is a -periodic function defined by for , for and the vector fields and are related by an involutive diffeomorphism.