A Dvoretzky-Kiefer-Wolfowitz type inequality for the Kaplan-Meier estimator
A sensitivity analysis for causal parameters in structural proportional hazards models.
Deviations from assigned treatment occur often in clinical trials. In such a setting, the traditional intent-to-treat analysis does not measure biological efficacy but rather programmatic effectiveness. For all-or-nothing compliance situation, Loeys and Goetghebeur (2003) recently proposed a Structural Proportional Hazards method. It allows for casual estimation in the complier subpopulation provided the exclusion restriction holds: randomization per se has no effect unless exposure has changed....
Additive hazards regression with case-cohort sampled current status data
In a case-cohort design, covariate histories are measured only on cases and a subcohort that is randomly selected from the entire cohort. This design has been widely used in large epidemiologic studies, especially when the exposures of interest are expensive to assemble for all the subjects. In this paper, we propose statistical procedures for analyzing case-cohort sampled current status data under the additive hazards model. Asymptotical properties of the proposed estimator are described and we...
Almost complete convergence of a recursive kernel estimator of the density with complete and censored independent data
In this paper, we firstly introduce a recursive kernel estimator of the density in the censored data case. Then, we establish its pointwise and uniform almost complete convergences, with rates, in both complete and censored independent data. Finally, we illustrate the accuracy of the proposed estimators throughout a simulation study.
Análisis de duración mediante un modelo lineal generalizado semiparamétrico.
Aitkin y Clayton (1980) proponen el análisis de modelos de duración mediante modelos lineales generalizados. En este trabajo extendemos esta metodología permitiendo que el efecto de alguna de las variables explicativas pueda no ser especificado. Así, el modelo propuesto es un modelo lineal generalizado semiparamétrico, con una componente paramétrica donde se especifica la forma funcional concreta del efecto de las variables explicativas sobre la duración, y una componente no paramétrica donde recogemos...
Analytical bootstrap methods for censored data.
Aspects of analysis of multivariate failure time data.
Multivariate failure time data arise in various forms including recurrent event data when individuals are followed to observe the sequence of occurrences of a certain type of event; correlated failure time when an individual is followed for the occurrence of two or more types of events for which the individual is simultaneously at risk, or when distinct individuals have depending event times; or more complicated multistate processes where individuals may move among a number of discrete states over...
Assessing influence in survival data with a cured fraction and covariates.
Diagnostic methods have been an important tool in regression analysis to detect anomalies, such as departures from error assumptions and the presence of outliers and influential observations with the fitted models. Assuming censored data, we considered a classical analysis and Bayesian analysis assuming no informative priors for the parameters of the model with a cure fraction. A Bayesian approach was considered by using Markov Chain Monte Carlo Methods with Metropolis-Hasting algorithms steps to...
Bayes estimation of the reliability function and hazard rate of a Weibull failure time distribution.
Given the recorded life times from a Weibull distribution, Bayes estimates of the reliability function and hazard rate are obtained using the posterior distributions and some recent results on Bayesian approximations due to Lindley (1980). Based on a Monte Carlo study, these estimates are compared with their maximum likelihood counterparts.
Bayesian approach for joint longitudinal and time-to-event data with survival fraction.
Bayesian reference analysis for proportional hazards model of random censorship with Weibull distribution
This article deals with the objective Bayesian analysis of random censorship model with informative censoring using Weibull distribution. The objective Bayesian analysis has a long history from Bayes and Laplace through Jeffreys and is reaching the level of sophistication gradually. The reference prior method of Bernardo is a nice attempt in this direction. The reference prior method is based on the Kullback-Leibler divergence between the prior and the corresponding posterior distribution and easy...
Behaviour of higher-order approximations of the tests in the single parameter Cox proportional hazards model
Survival analysis is applied in a wide range of sectors (medicine, economy, etc.), and its main idea is based on evaluating the time until the occurrence of an event of interest. The effect of some particular covariates on survival time is usually described by the Cox proportional hazards model and the statistical significance of the impact of covariates is verified by the likelihood ratio test, the Wald test, or the score test. In addition to standard tests, appropriate higher-order approximations...
Bias correction on censored least squares regression models
This paper proposes a bias reduction of the coefficients' estimator for linear regression models when observations are randomly censored and the error distribution is unknown. The proposed bias correction is applied to the weighted least squares estimator proposed by Stute [28] [W. Stute: Consistent estimation under random censorship when covariables are present. J. Multivariate Anal. 45 (1993), 89-103.], and it is based on model-based bootstrap resampling techniques that also allow us to work with...
Checking proportional rates in the two-sample transformation model
Transformation models for two samples of censored data are considered. Main examples are the proportional hazards and proportional odds model. The key assumption of these models is that the ratio of transformation rates (e. g., hazard rates or odds rates) is constant in time. A~method of verification of this proportionality assumption is developed. The proposed procedure is based on the idea of Neyman's smooth test and its data-driven version. The method is suitable for detecting monotonic as well...
Cumulative processes related to event histories.
Costs or benefits which accumulate for individuals over time are of interest in many life history processes. Familiar examples include costs of health care for persons with chronic medical conditions, the payments to insured persons during periods of disability, and quality of life which is sometimes used in the evaluation of treatments in terminally ill patients. For convenience, here we use the term costs to refer to cost or other cumulative measures. Two important scenarios are (i) where costs...
Dynamic dependence ordering for Archimedean copulas and distorted copulas
This paper proposes a general framework to compare the strength of the dependence in survival models, as time changes, i. e. given remaining lifetimes , to compare the dependence of given , and given , where . More precisely, analytical results will be obtained in the case the survival copula of is either Archimedean or a distorted copula. The case of a frailty based model will also be discussed in details.
Empirical analysis of current status data for additive hazards model with auxiliary covariates
In practice, it often occurs that some covariates of interest are not measured because of various reasons, but there may exist some auxiliary information available. In this case, an issue of interest is how to make use of the available auxiliary information for statistical analysis. This paper discusses statistical inference problems in the context of current status data arising from an additive hazards model with auxiliary covariates. An empirical log-likelihood ratio statistic for the regression...
Empirical comparison between the Nelson-Aalen Estimator and the Naive Local Constant Estimator.
The Nelson-Aalen estimator is widely used in biostatistics as a non-parametric estimator of the cumulative hazard function based on a right censored sample. A number of alternative estimators can be mentioned, namely, the naive local constant estimator (Guillén, Nielsen and Pérez-Marín, 2007) which provides improved bias versus variance properties compared to the traditional Nelson-Aalen estimator. Nevertheless, an empirical comparison of these two estimators has never been carried out. In this...
Estimation of the parameters of the reversed generalized logistic distribution with progressive censoring data.
Estudios de supervivencia con datos no observados. Dificultades inherentes al enfoque paramétrico.
A partir de una muestra de datos de supervivencia que contiene valores no observados en las covariantes de interés, presentamos una metodología que permite extraer toda la información contenida en covariantes completamente observadas, que estén fuertemente correlacionadas con las citadas covariantes de interés. El enfoque utilizado es completamente paramétrico y se basa en el método de máxima verosimilitud. Mostramos las dificultades, tanto de índole práctica como filosófica, que aparecen en la...