Deviations from assigned treatment occur often in clinical trials. In such a setting, the traditional intent-to-treat analysis does not measure biological efficacy but rather programmatic effectiveness. For all-or-nothing compliance situation, Loeys and Goetghebeur (2003) recently proposed a Structural Proportional Hazards method. It allows for casual estimation in the complier subpopulation provided the exclusion restriction holds: randomization per se has no effect unless exposure has changed....

In a case-cohort design, covariate histories are measured only on cases and a subcohort that is randomly selected from the entire cohort. This design has been widely used in large epidemiologic studies, especially when the exposures of interest are expensive to assemble for all the subjects. In this paper, we propose statistical procedures for analyzing case-cohort sampled current status data under the additive hazards model. Asymptotical properties of the proposed estimator are described and we...

Aitkin y Clayton (1980) proponen el análisis de modelos de duración mediante modelos lineales generalizados. En este trabajo extendemos esta metodología permitiendo que el efecto de alguna de las variables explicativas pueda no ser especificado. Así, el modelo propuesto es un modelo lineal generalizado semiparamétrico, con una componente paramétrica donde se especifica la forma funcional concreta del efecto de las variables explicativas sobre la duración, y una componente no paramétrica donde recogemos...

Multivariate failure time data arise in various forms including recurrent event data when individuals are followed to observe the sequence of occurrences of a certain type of event; correlated failure time when an individual is followed for the occurrence of two or more types of events for which the individual is simultaneously at risk, or when distinct individuals have depending event times; or more complicated multistate processes where individuals may move among a number of discrete states over...

Diagnostic methods have been an important tool in regression analysis to detect anomalies, such as departures from error assumptions and the presence of outliers and influential observations with the fitted models. Assuming censored data, we considered a classical analysis and Bayesian analysis assuming no informative priors for the parameters of the model with a cure fraction. A Bayesian approach was considered by using Markov Chain Monte Carlo Methods with Metropolis-Hasting algorithms steps to...

Given the recorded life times from a Weibull distribution, Bayes estimates of the reliability function and hazard rate are obtained using the posterior distributions and some recent results on Bayesian approximations due to Lindley (1980). Based on a Monte Carlo study, these estimates are compared with their maximum likelihood counterparts.

This article deals with the objective Bayesian analysis of random censorship model with informative censoring using Weibull distribution. The objective Bayesian analysis has a long history from Bayes and Laplace through Jeffreys and is reaching the level of sophistication gradually. The reference prior method of Bernardo is a nice attempt in this direction. The reference prior method is based on the Kullback-Leibler divergence between the prior and the corresponding posterior distribution and easy...

Survival analysis is applied in a wide range of sectors (medicine, economy, etc.), and its main idea is based on evaluating the time until the occurrence of an event of interest. The effect of some particular covariates on survival time is usually described by the Cox proportional hazards model and the statistical significance of the impact of covariates is verified by the likelihood ratio test, the Wald test, or the score test. In addition to standard tests, appropriate higher-order approximations...

This paper proposes a bias reduction of the coefficients' estimator for linear regression models when observations are randomly censored and the error distribution is unknown. The proposed bias correction is applied to the weighted least squares estimator proposed by Stute [28] [W. Stute: Consistent estimation under random censorship when covariables are present. J. Multivariate Anal. 45 (1993), 89-103.], and it is based on model-based bootstrap resampling techniques that also allow us to work with...

Transformation models for two samples of censored data are considered. Main examples are the proportional hazards and proportional odds model. The key assumption of these models is that the ratio of transformation rates (e. g., hazard rates or odds rates) is constant in time. A~method of verification of this proportionality assumption is developed. The proposed procedure is based on the idea of Neyman's smooth test and its data-driven version. The method is suitable for detecting monotonic as well...

Costs or benefits which accumulate for individuals over time are of interest in many life history processes. Familiar examples include costs of health care for persons with chronic medical conditions, the payments to insured persons during periods of disability, and quality of life which is sometimes used in the evaluation of treatments in terminally ill patients. For convenience, here we use the term costs to refer to cost or other cumulative measures. Two important scenarios are (i) where costs...

This paper proposes a general framework to compare the strength of the dependence in survival models, as time changes, i. e. given remaining lifetimes $X$, to compare the dependence of $X$ given $X>t$, and $X$ given $X>s$, where $s>t$. More precisely, analytical results will be obtained in the case the survival copula of $X$ is either Archimedean or a distorted copula. The case of a frailty based model will also be discussed in details.

In practice, it often occurs that some covariates of interest are not measured because of various reasons, but there may exist some auxiliary information available. In this case, an issue of interest is how to make use of the available auxiliary information for statistical analysis. This paper discusses statistical inference problems in the context of current status data arising from an additive hazards model with auxiliary covariates. An empirical log-likelihood ratio statistic for the regression...

The Nelson-Aalen estimator is widely used in biostatistics as a non-parametric estimator of the cumulative hazard function based on a right censored sample. A number of alternative estimators can be mentioned, namely, the naive local constant estimator (Guillén, Nielsen and Pérez-Marín, 2007) which provides improved bias versus variance properties compared to the traditional Nelson-Aalen estimator. Nevertheless, an empirical comparison of these two estimators has never been carried out. In this...

A partir de una muestra de datos de supervivencia que contiene valores no observados en las covariantes de interés, presentamos una metodología que permite extraer toda la información contenida en covariantes completamente observadas, que estén fuertemente correlacionadas con las citadas covariantes de interés. El enfoque utilizado es completamente paramétrico y se basa en el método de máxima verosimilitud. Mostramos las dificultades, tanto de índole práctica como filosófica, que aparecen en la...

The subject of this paper is to estimate adaptively the common probability density of $n$ independent, identically distributed random variables. The estimation is done at a fixed point $x_0\in ℝ$, over the density functions that belong to the Sobolev class $W_n(\beta ,L)$. We consider the adaptive problem setup, where the regularity parameter $\beta$ is unknown and varies in a given set $B_n$. A sharp adaptive estimator is obtained, and the explicit asymptotical constant, associated to its rate of convergence is found.