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Mathematical Modeling of Leukemogenesis and Cancer Stem Cell Dynamics

T. Stiehl, A. Marciniak-Czochra (2012)

Mathematical Modelling of Natural Phenomena

The cancer stem cell hypothesis has evolved to one of the most important paradigms in biomedical research. During recent years evidence has been accumulating for the existence of stem cell-like populations in different cancers, especially in leukemias. In the current work we propose a mathematical model of cancer stem cell dynamics in leukemias. We apply the model to compare cellular properties of leukemic stem cells to those of their benign counterparts....

Minimax and bayes estimation in deconvolution problem*

Mikhail Ermakov (2008)

ESAIM: Probability and Statistics

We consider a deconvolution problem of estimating a signal blurred with a random noise. The noise is assumed to be a stationary Gaussian process multiplied by a weight function function εh where h ∈ L2(R1) and ε is a small parameter. The underlying solution is assumed to be infinitely differentiable. For this model we find asymptotically minimax and Bayes estimators. In the case of solutions having finite number of derivatives similar results were obtained in [G.K. Golubev and R.Z. Khasminskii,...

Minimum variance importance sampling via Population Monte Carlo

R. Douc, A. Guillin, J.-M. Marin, C. P. Robert (2007)

ESAIM: Probability and Statistics

Variance reduction has always been a central issue in Monte Carlo experiments. Population Monte Carlo can be used to this effect, in that a mixture of importance functions, called a D-kernel, can be iteratively optimized to achieve the minimum asymptotic variance for a function of interest among all possible mixtures. The implementation of this iterative scheme is illustrated for the computation of the price of a European option in the Cox-Ingersoll-Ross model. A Central Limit theorem as well...

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