Berwald-moor metrics and structural stability of conformally-deformed geodesic SODE.
Biochemical network of drug-induced enzyme production: Parameter estimation based on the periodic dosing response measurement
The well-known bottleneck of systems pharmacology, i. e., systems biology applied to pharmacology, refers to the model parameters determination from experimentally measured datasets. This paper represents the development of our earlier studies devoted to inverse (ill-posed) problems of model parameters identification. The key feature of this research is the introduction of control (or periodic forcing by an input signal being a drug intake) of the nonlinear model of drug-induced enzyme production...