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Modeling and Simulating Asymmetrical Conductance Changes in Gramicidin Pores

Shixin Xu, Minxin Chen, Sheereen Majd, Xingye Yue, Chun Liu (2014)

Molecular Based Mathematical Biology

Gramicidin A is a small and well characterized peptide that forms an ion channel in lipid membranes. An important feature of gramicidin A (gA) pore is that its conductance is affected by the electric charges near the its entrance. This property has led to the application of gramicidin A as a biochemical sensor for monitoring and quantifying a number of chemical and enzymatic reactions. Here, a mathematical model of conductance changes of gramicidin A pores in response to the presence of electrical...

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