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Optimal Control of a Cancer Cell Model with Delay

C. Collins, K.R. Fister, M. Williams (2010)

Mathematical Modelling of Natural Phenomena

In this paper, we look at a model depicting the relationship of cancer cells in different development stages with immune cells and a cell cycle specific chemotherapy drug. The model includes a constant delay in the mitotic phase. By applying optimal control theory, we seek to minimize the cost associated with the chemotherapy drug and to minimize the number of tumor cells. Global existence of a solution has been shown for this model and existence...

Optimal control of a frictionless contact problem with normal compliance

Arezki Touzaline (2018)

Commentationes Mathematicae Universitatis Carolinae

We consider a mathematical model which describes a contact between an elastic body and a foundation. The contact is frictionless with normal compliance. The goal of this paper is to study an optimal control problem which consists of leading the stress tensor as close as possible to a given target, by acting with a control on the boundary of the body. We state an optimal control problem which admits at least one solution. Next, we establish an optimality condition corresponding to a regularization...

Optimal control of a rotating body beam

Weijiu Liu (2002)

ESAIM: Control, Optimisation and Calculus of Variations

In this paper we consider the problem of optimal control of the model for a rotating body beam, which describes the dynamics of motion of a beam attached perpendicularly to the center of a rigid cylinder and rotating with the cylinder. The control is applied on the cylinder via a torque to suppress the vibrations of the beam. We prove that there exists at least one optimal control and derive a necessary condition for the control. Furthermore, on the basis of iteration method, we propose numerical...

Optimal Control of a Rotating Body Beam

Weijiu Liu (2010)

ESAIM: Control, Optimisation and Calculus of Variations

In this paper we consider the problem of optimal control of the model for a rotating body beam, which describes the dynamics of motion of a beam attached perpendicularly to the center of a rigid cylinder and rotating with the cylinder. The control is applied on the cylinder via a torque to suppress the vibrations of the beam. We prove that there exists at least one optimal control and derive a necessary condition for the control. Furthermore, on the basis of iteration method, we propose ...

Optimal control of a stochastic heat equation with boundary-noise and boundary-control

Arnaud Debussche, Marco Fuhrman, Gianmario Tessitore (2007)

ESAIM: Control, Optimisation and Calculus of Variations

We are concerned with the optimal control of a nonlinear stochastic heat equation on a bounded real interval with Neumann boundary conditions. The specificity here is that both the control and the noise act on the boundary. We start by reformulating the state equation as an infinite dimensional stochastic evolution equation. The first main result of the paper is the proof of existence and uniqueness of a mild solution for the corresponding Hamilton-Jacobi-Bellman (HJB) equation. The C1 regularity...

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