Pravděpodobnostní model spontánní vzruchové aktivity neuronu
Early studies of the novel swine-origin 2009 influenza A (H1N1) epidemic indicate clinical attack rates in children much higher than in adults. Non-medical interventions such as school closings are constrained by their large socio-economic costs. Here we develop a mathematical model to ascertain the roles of pre-symptomatic influenza transmission as well as symptoms surveillance of children to assess the utility of school closures. Our model analysis...
Motivated by the development of efficient Monte Carlo methods for PDE models in molecular dynamics, we establish a new probabilistic interpretation of a family of divergence form operators with discontinuous coefficients at the interface of two open subsets of . This family of operators includes the case of the linearized Poisson-Boltzmann equation used to compute the electrostatic free energy of a molecule. More precisely, we explicitly construct a Markov process whose infinitesimal generator...
The classical theory of the sex-ratio evolution, known as the sex-ratio game, is based on the maximization of the number of grandchildren, treated as a fitness measure of a female producing offspring of the sex ratio that is coded in her genes. The theory predicts that it is more profitable to produce offspring with less numerous sex. We can find in the literature mutually exclusive conclusions based on this prediction: some textbooks say that populations with the equal number of sons and daughters...
This review outlines the recent progress made in developing more accurate and efficient solutions to model electrostatics in systems comprised of bio-macromolecules and nanoobjects, the last one referring to objects that do not have biological function themselves but nowadays are frequently used in biophysical and medical approaches in conjunction with bio-macromolecules. The problem of modeling macromolecular electrostatics is reviewed from two different angles: as a mathematical task provided...
In this review paper we consider physiologically structured population models that have been widely studied and employed in the literature to model the dynamics of a wide variety of populations. However in a number of cases these have been found inadequate to describe some phenomena arising in certain real-world applications such as dispersion in the structure variables due to growth uncertainty/variability. Prompted by this, we described two recent...
Recently, data on multiple gene expression at sequential time points were analyzed using the Singular Value Decomposition (SVD) as a means to capture dominant trends, called characteristic modes, followed by the fitting of a linear discrete-time dynamical system in which the expression values at a given time point are linear combinations of the values at a previous time point. We attempt to address several aspects of the method. To obtain the model, we formulate a nonlinear optimization problem...
We present an extension of the protector control scheme introduced for the linear case in a previous work to a class of nonlinear systems. The systems considered are assumed to have a finite propagation velocity while the initial state is subject to a spreading disturbance. We characterize such a control first by using the remediability approach to the resulting nonlinear delay system, and then by coupling families of transformations and the delay approach. To illustrate this work, we provide a...