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Spatial Dynamics of Contact-Activated Fibrin Clot Formation in vitro and in silico in Haemophilia B: Effects of Severity and Ahemphil B Treatment

A. A. Tokarev, Yu. V. Krasotkina, M. V. Ovanesov, M. A. Panteleev, M. A. Azhigirova, V. A. Volpert, F. I. Ataullakhanov, A. A. Butilin (2010)

Mathematical Modelling of Natural Phenomena

Spatial dynamics of fibrin clot formation in non-stirred system activated by glass surface was studied as a function of FIX activity. Haemophilia B plasma was obtained from untreated patients with different levels of FIX deficiency and from severe haemophilia B patient treated with FIX concentrate (Ahemphil B) during its clearance with half-life t1/2=12 hours. As reported previously (Ataullakhanov et al. Biochim Biophys Acta 1998; 1425: 453-468), clot growth in space showed two distinct phases:...

Spatial stochastic predator-prey models

Mauro Mobilia, Ivan T. Georgiev, Uwe C. Täuber (2008)

Banach Center Publications

We consider a broad class of stochastic lattice predator-prey models whose main features are overviewed. In particular, this article aims at drawing a picture of the influence of spatial fluctuations, which are not accounted for by the deterministic rate equations, on the properties of the stochastic models. Here, we outline the robust scenario obeyed by most of the lattice predator-prey models with an interaction à la Lotka-Volterra. We also show how a drastically different behavior can emerge...

Spatiotemporal Dynamics in a Spatial Plankton System

R. K. Upadhyay, W. Wang, N. K. Thakur (2010)

Mathematical Modelling of Natural Phenomena

In this paper, we investigate the complex dynamics of a spatial plankton-fish system with Holling type III functional responses. We have carried out the analytical study for both one and two dimensional system in details and found out a condition for diffusive instability of a locally stable equilibrium. Furthermore, we present a theoretical analysis of processes of pattern formation that involves organism distribution and their interaction of spatially...

Spatio-Temporal Modelling of the p53–mdm2 Oscillatory System

K. E. Gordon, I. M.M. van Leeuwen, S. Laín, M. A.J. Chaplain (2009)

Mathematical Modelling of Natural Phenomena

In this paper we investigate the role of spatial effects in determining the dynamics of a subclass of signalling pathways characterised by their ability to demonstrate oscillatory behaviour. To this end, we formulate a simple spatial model of the p53 network that accounts for both a negative feedback and a transcriptional delay. We show that the formation of protein density patterns can depend on the shape of the cell, position of the nucleus, and the protein diffusion rates. The temporal...

Spread Pattern Formation of H5N1-Avian Influenza and its Implications for Control Strategies

R. Liu, V. R. S. K. Duvvuri, J. Wu (2008)

Mathematical Modelling of Natural Phenomena

Mechanisms contributing to the spread of avian influenza seem to be well identified, but how their interplay led to the current worldwide spread pattern of H5N1 influenza is still unknown due to the lack of effective global surveillance and relevant data. Here we develop some deterministic models based on the transmission cycle and modes of H5N1 and focusing on the interaction among poultry, wild birds and environment. Some of the model parameters are obtained from existing literatures, and others...

Stability Analysis of Cell Dynamics in Leukemia

H. Özbay, C. Bonnet, H. Benjelloun, J. Clairambault (2012)

Mathematical Modelling of Natural Phenomena

In order to better understand the dynamics of acute leukemia, and in particular to find theoretical conditions for the efficient delivery of drugs in acute myeloblastic leukemia, we investigate stability of a system modeling its cell dynamics. The overall system is a cascade connection of sub-systems consisting of distributed delays and static nonlinear feedbacks. Earlier results on local asymptotic stability are improved by the analysis of the linearized...

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