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Cell Modelling of Hematopoiesis

N. Bessonov, L. Pujo-Menjouet, V. Volpert (2010)

Mathematical Modelling of Natural Phenomena

In this work, we introduce a new software created to study hematopoiesis at the cell population level with the individually based approach. It can be used as an interface between theoretical works on population dynamics and experimental observations. We show that this software can be useful to study some features of normal hematopoiesis as well as some blood diseases such as myelogenous leukemia. It is also possible to simulate cell communication and the formation of cell colonies in the bone marrow. ...

Counting number of cells and cell segmentation using advection-diffusion equations

Peter Frolkovič, Karol Mikula, Nadine Peyriéras, Alex Sarti (2007)

Kybernetika

We develop a method for counting number of cells and extraction of approximate cell centers in 2D and 3D images of early stages of the zebra-fish embryogenesis. The approximate cell centers give us the starting points for the subjective surface based cell segmentation. We move in the inner normal direction all level sets of nuclei and membranes images by a constant speed with slight regularization of this flow by the (mean) curvature. Such multi- scale evolutionary process is represented by a geometrical...

Delay Model of Hematopoietic Stem Cell Dynamics: Asymptotic Stability and Stability Switch

F. Crauste (2009)

Mathematical Modelling of Natural Phenomena

A nonlinear system of two delay differential equations is proposed to model hematopoietic stem cell dynamics. Each equation describes the evolution of a sub-population, either proliferating or nonproliferating. The nonlinearity accounting for introduction of nonproliferating cells in the proliferating phase is assumed to depend upon the total number of cells. Existence and stability of steady states are investigated. A Lyapunov functional is built to obtain the global asymptotic stability of the...

Dynamics of Erythroid Progenitors and Erythroleukemia

N. Bessonov, F. Crauste, I. Demin, V. Volpert (2009)

Mathematical Modelling of Natural Phenomena

The paper is devoted to mathematical modelling of erythropoiesis, production of red blood cells in the bone marrow. We discuss intra-cellular regulatory networks which determine self-renewal and differentiation of erythroid progenitors. In the case of excessive self-renewal, immature cells can fill the bone marrow resulting in the development of leukemia. We introduce a parameter characterizing the strength of mutation. Depending on its value, leukemia will or will not develop. The simplest...

Dynamics of Propagation Phenomena in Biological Pattern Formation

G. Liţcanu, J. J.L. Velázquez (2010)

Mathematical Modelling of Natural Phenomena

A large variety of complex spatio-temporal patterns emerge from the processes occurring in biological systems, one of them being the result of propagating phenomena. This wave-like structures can be modelled via reaction-diffusion equations. If a solution of a reaction-diffusion equation represents a travelling wave, the shape of the solution will be the same at all time and the speed of propagation of this shape will be a constant. Travelling wave solutions of reaction-diffusion systems have been...

Enumerated type semantics for the calculus of looping sequences

Livio Bioglio (2011)

RAIRO - Theoretical Informatics and Applications - Informatique Théorique et Applications

The calculus of looping sequences is a formalism for describing the evolution of biological systems by means of term rewriting rules. In this paper we enrich this calculus with a type discipline which preserves some biological properties depending on the minimum and the maximum number of elements of some type requested by the present elements. The type system enforces these properties and typed reductions guarantee that evolution preserves them. As an example, we model the hemoglobin structure and...

Enumerated type semantics for the calculus of looping sequences

Livio Bioglio (2011)

RAIRO - Theoretical Informatics and Applications

The calculus of looping sequences is a formalism for describing the evolution of biological systems by means of term rewriting rules. In this paper we enrich this calculus with a type discipline which preserves some biological properties depending on the minimum and the maximum number of elements of some type requested by the present elements. The type system enforces these properties and typed reductions guarantee that evolution preserves them. As an example, we model the hemoglobin structure...

High Resolution Tracking of Cell Membrane Dynamics in Moving Cells: an Electrifying Approach

R.A. Tyson, D.B.A. Epstein, K.I. Anderson, T. Bretschneider (2010)

Mathematical Modelling of Natural Phenomena

Cell motility is an integral part of a diverse set of biological processes. The quest for mathematical models of cell motility has prompted the development of automated approaches for gathering quantitative data on cell morphology, and the distribution of molecular players involved in cell motility. Here we review recent approaches for quantifying cell motility, including automated cell segmentation and tracking. Secondly, we present our own novel...

Homogenization of a carcinogenesis model with different scalings with the homogenization parameter

Isabell Graf, Malte A. Peter (2014)

Mathematica Bohemica

In the context of periodic homogenization based on two-scale convergence, we homogenize a linear system of four coupled reaction-diffusion equations, two of which are defined on a manifold. The system describes the most important subprocesses modeling the carcinogenesis of a human cell caused by Benzo-[a]-pyrene molecules. These molecules are activated to carcinogens in a series of chemical reactions at the surface of the endoplasmic reticulum, which constitutes a fine structure inside the cell....

Host Factors in Viral Life Cycles

G. Pérez-Vilaró, J. Jungfleisch, V. Saludes, N. Scheller, M. Giménez-Barcons, J. Díez (2012)

Mathematical Modelling of Natural Phenomena

Viruses are obligate intracellular parasites that rely on the host cell for expansion. With the development of global analyses techniques like transcriptomics, proteomics and siRNA library screening of complete cellular gene sets, a large range of host cell factors have been discovered that either support or restrict virus growth. Here we summarize some of the recent findings and focus our discussion on the hepatitis C virus and the human immunodeficiency...

Immunotherapy with interleukin-2: A study based on mathematical modeling

Sandip Banerjee (2008)

International Journal of Applied Mathematics and Computer Science

The role of interleukin-2 (IL-2) in tumor dynamics is illustrated through mathematical modeling, using delay differential equations with a discrete time delay (a modified version of the Kirshner-Panetta model). Theoretical analysis gives an expression for the discrete time delay and the length of the time delay to preserve stability. Numerical analysis shows that interleukin-2 alone can cause the tumor cell population to regress.

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