EuDML | Browse

Page 1

Displaying 1 – 5 of 5

The EM algorithm and its implementation for the estimation of frequencies of SNP-haplotypes

Joanna Polańska (2003)

International Journal of Applied Mathematics and Computer Science

A haplotype analysis is becoming increasingly important in studying complex genetic diseases. Various algorithms and specialized computer software have been developed to statistically estimate haplotype frequencies from marker phenotypes in unrelated individuals. However, currently there are very few empirical reports on the performance of the methods for the recovery of haplotype frequencies. One of the most widely used methods of haplotype reconstruction is the Maximum Likelihood method, employing...

The Influence of Look-Ahead on the Error Rate of Transcription

Y. R. Yamada, C. S. Peskin (2010)

Mathematical Modelling of Natural Phenomena

In this paper we study the error rate of RNA synthesis in the look-ahead model for the random walk of RNA polymerase along DNA during transcription. The model’s central assumption is the existence of a window of activity in which ribonucleoside triphosphates (rNTPs) bind reversibly to the template DNA strand before being hydrolyzed and linked covalently to the nascent RNA chain. An unknown, but important, integer parameter of this model is the window...

The influence of symmetry on the probability of assembly pathways for icosahedral viral shells.

Bóna, Miklós, Sitharam, Meera (2008)

Computational & Mathematical Methods in Medicine

The resonance phenomenon in the reaction-diffusion systems.

Lobanov, A.I., Starozhilova, T.K., Chernyaev, A.P. (2001)

Discrete Dynamics in Nature and Society

Thermodynamics of DNA microarrays

Enrico Carlon (2008)

Banach Center Publications

DNA microarrays have been widely used in molecular biology laboratories. The main current application of these devices is the determination of the gene expression level for thousands of genes simultaneously. Here we review a recently introduced physical model for hybridization (i.e. the binding of complementary DNA strands) in Affymetrix arrays and compare it to experimental results. The experimental data follow rather well the microscopic model and the approach offers several advantages compared...