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A biophysical model describing long-range cell-to-cell communication by a diffusible
signal mediated by autocrine loops in developing epithelia in the presence of a
morphogenetic pre-pattern is introduced. Under a number of approximations, the model
reduces to a particular kind of bistable reaction-diffusion equation with strong
heterogeneity. In the case of the heterogeneity in the form of a long strip a detailed
analysis of signal propagation is...
In proteomics study, Imaging Mass Spectrometry (IMS) is an emerging and very promising
new technique for protein analysis from intact biological tissues. Though it has shown
great potential and is very promising for rapid mapping of protein localization and the
detection of sizeable differences in protein expression, challenges remain in data
processing due to the difficulty of high dimensionality and the fact that the number of
input variables in...
Natural immunity to breast and prostate cancers is predicted by a novel, saturated
ordered mutation model fitted to USA (SEER) incidence data, a prediction consistent with
the latest ideas in immunosurveillance. For example, the prevalence of natural immunity to
breast cancer in the white female risk population is predicted to be 76.5%; this immunity
may be genetic and, therefore, inherited. The modeling also predicts that 6.9% of White
Females are...
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