Identifying generalized Fitzhugh-Nagumo equation from a numerical solution of Hodgkin-Huxley model.
Immunotherapy with interleukin-2: A study based on mathematical modeling
The role of interleukin-2 (IL-2) in tumor dynamics is illustrated through mathematical modeling, using delay differential equations with a discrete time delay (a modified version of the Kirshner-Panetta model). Theoretical analysis gives an expression for the discrete time delay and the length of the time delay to preserve stability. Numerical analysis shows that interleukin-2 alone can cause the tumor cell population to regress.
Infinite time regular synthesis
Infinite time regular synthesis
In this paper we provide a new sufficiency theorem for regular syntheses. The concept of regular synthesis is discussed in [12], where a sufficiency theorem for finite time syntheses is proved. There are interesting examples of optimal syntheses that are very regular, but whose trajectories have time domains not necessarily bounded. The regularity assumptions of the main theorem in [12] are verified by every piecewise smooth feedback control generating extremal trajectories that reach the target...
Infinite-dimensional Sylvester equations: Basic theory and application to observer design
This paper develops a mathematical framework for the infinite-dimensional Sylvester equation both in the differential and the algebraic form. It uses the implemented semigroup concept as the main mathematical tool. This concept may be found in the literature on evolution equations occurring in mathematics and physics and is rather unknown in systems and control theories. But it is just systems and control theory where Sylvester equations widely appear, and for this reason we intend to give a mathematically...