On oscillatory solutions of third-order linear differential equations
A pharmacodynamic model introduced earlier in the literature for in silico prediction of rifampicin-induced CYP3A4 enzyme production is described and some aspects of the involved curve-fitting based parameter estimation are discussed. Validation with our own laboratory data shows that the quality of the fit is particularly sensitive with respect to an unknown parameter representing the concentration of the nuclear receptor PXR (pregnane X receptor). A detailed analysis of the influence of that parameter...
In this paper we study nonlinear second order differential equations subject to separated linear boundary conditions and to linear impulse conditions. Sign properties of an associated Green’s function are investigated and existence results for positive solutions of the nonlinear boundary value problem with impulse are established. Upper and lower bounds for positive solutions are also given.
The differential equation of the form , a ∈ (0,∞), is considered and solutions u with u(0) = 0 and (u(t))² + (u’(t))² > 0 on (0,∞) are studied. Theorems about existence, uniqueness, boundedness and dependence of solutions on a parameter are given.