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On parameter estimation in an in vitro compartmental model for drug-induced enzyme production in pharmacotherapy

Jurjen Duintjer Tebbens, Ctirad Matonoha, Andreas Matthios, Štěpán Papáček (2019)

Applications of Mathematics

A pharmacodynamic model introduced earlier in the literature for in silico prediction of rifampicin-induced CYP3A4 enzyme production is described and some aspects of the involved curve-fitting based parameter estimation are discussed. Validation with our own laboratory data shows that the quality of the fit is particularly sensitive with respect to an unknown parameter representing the concentration of the nuclear receptor PXR (pregnane X receptor). A detailed analysis of the influence of that parameter...

On positive solutions for a nonlinear boundary value problem with impulse

Huseyin Bereketoglu, Aydin Huseynov (2006)

Czechoslovak Mathematical Journal

In this paper we study nonlinear second order differential equations subject to separated linear boundary conditions and to linear impulse conditions. Sign properties of an associated Green’s function are investigated and existence results for positive solutions of the nonlinear boundary value problem with impulse are established. Upper and lower bounds for positive solutions are also given.

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