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A Hybrid Model Describing Different Morphologies of Tumor Invasion Fronts

M. Scianna, L. Preziosi (2012)

Mathematical Modelling of Natural Phenomena

The invasive capability is fundamental in determining the malignancy of a solid tumor. Revealing biomedical strategies that are able to partially decrease cancer invasiveness is therefore an important approach in the treatment of the disease and has given rise to multiple in vitro and in silico models. We here develop a hybrid computational framework, whose aim is to characterize the effects of the different cellular and subcellular mechanisms involved...

A hyperbolic model of chemotaxis on a network: a numerical study

G. Bretti, R. Natalini, M. Ribot (2014)

ESAIM: Mathematical Modelling and Numerical Analysis - Modélisation Mathématique et Analyse Numérique

In this paper we deal with a semilinear hyperbolic chemotaxis model in one space dimension evolving on a network, with suitable transmission conditions at nodes. This framework is motivated by tissue-engineering scaffolds used for improving wound healing. We introduce a numerical scheme, which guarantees global mass densities conservation. Moreover our scheme is able to yield a correct approximation of the effects of the source term at equilibrium. Several numerical tests are presented to show the...

A mathematical model describing the thyroid-pituitary axis with time delays in hormone transportation

Banibrata Mukhopadhyay, Rakhi Bhattacharyya (2006)

Applications of Mathematics

In the present paper, a mathematical model, originally proposed by Danziger and Elmergreen and describing the thyroid-pituitary homeostatic mechanism, is modified and analyzed for its physiological and clinical significance. The influence of different system parameters on the stability behavior of the system is discussed. The transportation delays of different hormones in the bloodstream, both in the discrete and distributed forms, are considered. Delayed models are analyzed regarding the stability...

A mathematical model for fluid-glucose-albumin transport in peritoneal dialysis

Roman Cherniha, Joanna Stachowska-Piętka, Jacek Waniewski (2014)

International Journal of Applied Mathematics and Computer Science

A mathematical model for fluid and solute transport in peritoneal dialysis is constructed. The model is based on a threecomponent nonlinear system of two-dimensional partial differential equations for fluid, glucose and albumin transport with the relevant boundary and initial conditions. Our aim is to model ultrafiltration of water combined with inflow of glucose to the tissue and removal of albumin from the body during dialysis, by finding the spatial distributions of glucose and albumin concentrations...

A Mathematical Model of Cancer Stem Cell Lineage Population Dynamics with Mutation Accumulation and Telomere Length Hierarchies

G. Kapitanov (2012)

Mathematical Modelling of Natural Phenomena

There is evidence that cancer develops when cells acquire a sequence of mutations that alter normal cell characteristics. This sequence determines a hierarchy among the cells, based on how many more mutations they need to accumulate in order to become cancerous. When cells divide, they exhibit telomere loss and differentiate, which defines another cell hierarchy, on top of which is the stem cell. We propose a mutation-generation model, which combines...

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