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A weighted HP model for protein folding with diagonal contacts

Hans-Joachim Böckenhauer, Dirk Bongartz (2007)

RAIRO - Theoretical Informatics and Applications

The HP model is one of the most popular discretized models for attacking the protein folding problem, i.e., for the computational prediction of the tertiary structure of a protein from its amino acid sequence. It is based on the assumption that interactions between hydrophobic amino acids are the main force in the folding process. Therefore, it distinguishes between polar and hydrophobic amino acids only and tries to embed the amino acid sequence into a two- or three-dimensional grid lattice...

A within-host dengue infection model with immune response and nonlinear incidence rate

Hajar Ansari, Mahmoud Hesaaraki (2013)

Applicationes Mathematicae

A model of viral infection of monocytes population by the dengue virus is formulated as a system of four ordinary differential equations. The model takes into account the immune response and nonlinear incidence rate of susceptible and free virus particles. Global stability of the uninfected steady state is investigated. Such a steady state always exists. If it is the only steady state, then it is globally asymptotically stable. If any infected steady state exists, then the uninfected...

Accurate reduction of a model of circadian rhythms by delayed quasi-steady state assumptions

Tomáš Vejchodský (2014)

Mathematica Bohemica

Quasi-steady state assumptions are often used to simplify complex systems of ordinary differential equations in the modelling of biochemical processes. The simplified system is designed to have the same qualitative properties as the original system and to have a small number of variables. This enables to use the stability and bifurcation analysis to reveal a deeper structure in the dynamics of the original system. This contribution shows that introducing delays to quasi-steady state assumptions...

Addressing the problem of lack of representativeness on syndromic surveillance schemes

Isabel Natário, M. Lucília Carvalho (2009)

Discussiones Mathematicae Probability and Statistics

A major concern with some contagious diseases has recently led to an enormous effort to monitor population health status by several different means. This work presents a modeling approach to overcome this poor data characteristic, allowing its use for the estimation of the true population disease picture. We use a state space model, where we run two processes in parallel - a process describing the non observable states of the population concerning the presence/absence of disease,...

An Age and Spatially Structured Population Model for Proteus Mirabilis Swarm-Colony Development

Ph. Laurençot, Ch. Walker (2008)

Mathematical Modelling of Natural Phenomena

Proteus mirabilis are bacteria that make strikingly regular spatial-temporal patterns on agar surfaces. In this paper we investigate a mathematical model that has been shown to display these structures when solved numerically. The model consists of an ordinary differential equation coupled with a partial differential equation involving a first-order hyperbolic aging term together with nonlinear degenerate diffusion. The system is shown to admit global weak solutions.

An analytical iterative statistical algorithm for image reconstruction from projections

Robert Cierniak (2014)

International Journal of Applied Mathematics and Computer Science

The main purpose of the paper is to present a statistical model-based iterative approach to the problem of image reconstruction from projections. This originally formulated reconstruction algorithm is based on a maximum likelihood method with an objective adjusted to the probability distribution of measured signals obtained from an x-ray computed tomograph with parallel beam geometry. Various forms of objectives are tested. Experimental results show that an objective that is exactly tailored statistically...

An automatic hybrid method for retinal blood vessel extraction

Yong Yang, Shuying Huang, Nini Rao (2008)

International Journal of Applied Mathematics and Computer Science

The extraction of blood vessels from retinal images is an important and challenging task in medical analysis and diagnosis. This paper presents a novel hybrid automatic approach for the extraction of retinal image vessels. The method consists in the application of mathematical morphology and a fuzzy clustering algorithm followed by a purification procedure. In mathematical morphology, the retinal image is smoothed and strengthened so that the blood vessels are enhanced and the background information...

An Epidemic Model With Post-Contact Prophylaxis of Distributed Length II. Stability and Oscillations if Treatment is Fully Effective

H. R. Thieme, A. Tridane, Y. Kuang (2008)

Mathematical Modelling of Natural Phenomena

A possible control strategy against the spread of an infectious disease is the treatment with antimicrobials that are given prophylactically to those that had contact with an infective person. The treatment continues until recovery or until it becomes obvious that there was no infection in the first place. The model considers susceptible, treated uninfected exposed, treated infected, (untreated) infectious, and recovered individuals. The overly optimistic assumptions are made that treated uninfected...

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