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Biochemical network of drug-induced enzyme production: Parameter estimation based on the periodic dosing response measurement

Volodymyr Lynnyk, Štěpán Papáček, Branislav Rehák (2021)

Kybernetika

The well-known bottleneck of systems pharmacology, i. e., systems biology applied to pharmacology, refers to the model parameters determination from experimentally measured datasets. This paper represents the development of our earlier studies devoted to inverse (ill-posed) problems of model parameters identification. The key feature of this research is the introduction of control (or periodic forcing by an input signal being a drug intake) of the nonlinear model of drug-induced enzyme production...

Blow-up results for some reaction-diffusion equations with time delay

Hongliang Wang, Yujuan Chen, Haihua Lu (2012)

Annales Polonici Mathematici

We discuss the effect of time delay on blow-up of solutions to initial-boundary value problems for nonlinear reaction-diffusion equations. Firstly, two examples are given, which indicate that the delay can both induce and prevent the blow-up of solutions. Then we show that adding a new term with delay may not change the blow-up character of solutions.

Bound sets and two-point boundary value problems for second order differential systems

Jean Mawhin, Katarzyna Szymańska-Dębowska (2019)

Mathematica Bohemica

The solvability of second order differential systems with the classical separated or periodic boundary conditions is considered. The proofs use special classes of curvature bound sets or bound sets together with the simplest version of the Leray-Schauder continuation theorem. The special cases where the bound set is a ball, a parallelotope or a bounded convex set are considered.

Boundary Data Maps for Schrödinger Operators on a Compact Interval

S. Clark, F. Gesztesy, M. Mitrea (2010)

Mathematical Modelling of Natural Phenomena

We provide a systematic study of boundary data maps, that is, 2 × 2 matrix-valued Dirichlet-to-Neumann and more generally, Robin-to-Robin maps, associated with one-dimensional Schrödinger operators on a compact interval [0, R] with separated boundary conditions at 0 and R. Most of our results are formulated in the non-self-adjoint context. Our principal results include explicit representations of these boundary data maps in terms of the resolvent...

Boundary layer phenomenon for three -point boundary value problem for the nonlinear singularly perturbed systems

Robert Vrabel (2011)

Kybernetika

This paper deals with the three-point boundary value problem for the nonlinear singularly perturbed second-order systems. Especially, we focus on an analysis of the solutions in the right endpoint of considered interval from an appearance of the boundary layer point of view. We use the method of lower and upper solutions combined with analysis of the integral equation associated with the class of nonlinear systems considered here.

Boundary problems for generalized Lyapunov equations.

Lucas Jódar Sánchez (1986)

Stochastica

Boundary value problems for generalized Lyapunov equations whose coefficients are time-dependant bounded linear operators defined on a separable complex Hilbert space are studied. Necessary and sufficient conditions for the existence of solutions and explicit expressions of them are given.

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