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Spatio-Temporal Modelling of the p53–mdm2 Oscillatory System

K. E. Gordon, I. M.M. van Leeuwen, S. Laín, M. A.J. Chaplain (2009)

Mathematical Modelling of Natural Phenomena

In this paper we investigate the role of spatial effects in determining the dynamics of a subclass of signalling pathways characterised by their ability to demonstrate oscillatory behaviour. To this end, we formulate a simple spatial model of the p53 network that accounts for both a negative feedback and a transcriptional delay. We show that the formation of protein density patterns can depend on the shape of the cell, position of the nucleus, and the protein diffusion rates. The temporal...

Spectral properties of fourth order differential operators

Ondřej Došlý, Roman Hilscher (1997)

Mathematica Bohemica

Necessary and sufficient conditions for discreteness and boundedness below of the spectrum of the singular differential operator ( y ) 1 w ( t ) ( r ( t ) y ) , t [ a , ) are established. These conditions are based on a recently proved relationship between spectral properties of and oscillation of a certain associated second order differential equation.

Spread Pattern Formation of H5N1-Avian Influenza and its Implications for Control Strategies

R. Liu, V. R. S. K. Duvvuri, J. Wu (2008)

Mathematical Modelling of Natural Phenomena

Mechanisms contributing to the spread of avian influenza seem to be well identified, but how their interplay led to the current worldwide spread pattern of H5N1 influenza is still unknown due to the lack of effective global surveillance and relevant data. Here we develop some deterministic models based on the transmission cycle and modes of H5N1 and focusing on the interaction among poultry, wild birds and environment. Some of the model parameters are obtained from existing literatures, and others...

Stability analysis of uncertain complex-variable delayed nonlinear systems via intermittent control with multiple switched periods

Song Zheng (2018)

Kybernetika

In this paper, an intermittent control approach with multiple switched periods is proposed for the robust exponential stabilization of uncertain complex-variable delayed nonlinear systems with parameters perturbation, in which the considered complex systems have bounded parametric uncertainties. Based on the Lyapunov stability theory and comparison theorem of differential equations, some stability criteria are established for a class of uncertain complex delayed nonlinear systems with parameters...

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