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Cell Modelling of Hematopoiesis

N. Bessonov, L. Pujo-Menjouet, V. Volpert (2010)

Mathematical Modelling of Natural Phenomena

In this work, we introduce a new software created to study hematopoiesis at the cell population level with the individually based approach. It can be used as an interface between theoretical works on population dynamics and experimental observations. We show that this software can be useful to study some features of normal hematopoiesis as well as some blood diseases such as myelogenous leukemia. It is also possible to simulate cell communication and the formation of cell colonies in the bone marrow. ...

Chance constrained bottleneck transportation problem with preference of routes

Yue Ge, Minghao Chen, Hiroaki Ishii (2012)

Kybernetika

This paper considers a variant of the bottleneck transportation problem. For each supply-demand point pair, the transportation time is an independent random variable. Preference of each route is attached. Our model has two criteria, namely: minimize the transportation time target subject to a chance constraint and maximize the minimal preference among the used routes. Since usually a transportation pattern optimizing two objectives simultaneously does not exist, we define non-domination in this...

Chance constrained optimal beam design: Convex reformulation and probabilistic robust design

Jakub Kůdela, Pavel Popela (2018)

Kybernetika

In this paper, we are concerned with a civil engineering application of optimization, namely the optimal design of a loaded beam. The developed optimization model includes ODE-type constraints and chance constraints. We use the finite element method (FEM) for the approximation of the ODE constraints. We derive a convex reformulation that transforms the problem into a linear one and find its analytic solution. Afterwards, we impose chance constraints on the stress and the deflection of the beam....

Chance constrained problems: penalty reformulation and performance of sample approximation technique

Martin Branda (2012)

Kybernetika

We explore reformulation of nonlinear stochastic programs with several joint chance constraints by stochastic programs with suitably chosen penalty-type objectives. We show that the two problems are asymptotically equivalent. Simpler cases with one chance constraint and particular penalty functions were studied in [6,11]. The obtained problems with penalties and with a fixed set of feasible solutions are simpler to solve and analyze then the chance constrained programs. We discuss solving both problems...

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