Individual-based lattice model for spatial spread of epidemics.
Inferences for joint modelling of repeated ordinal scores and time to event data.
Influence of diffusion on interactions between malignant gliomas and immune system
We analyse the influence of diffusion and space distribution of cells in a simple model of interactions between an activated immune system and malignant gliomas, among which the most aggressive one is GBM Glioblastoma Multiforme. It turns out that diffusion cannot affect stability of spatially homogeneous steady states. This suggests that there are two possible outcomes-the solution is either attracted by the positive steady state or by the semitrivial one. The semitrivial steady state describes...
Influence of time delays on the Hahnfeldt et al. angiogenesis model dynamics
We study the influence of time delays on the dynamics of the general Hahnfeldt et al. model of an angiogenesis process. We analyse the dynamics of the system for different values of the parameter α which reflects the strength of stimulation of the vessel formation process. Time delays are introduced in three subprocesses: tumour growth, stimulation and inhibition of vessel formation (represented by endothelial cell dynamics). We focus on possible destabilisation of the positive steady state due...
Influenza Transmission in Preschools: Modulation by contact landscapes and interventions
Epidemiologic data suggest that schools and daycare facilities likely play a major role in the dissemination of influenza. Pathogen transmission within such small, inhomogenously mixed populations is difficult to model using traditional approaches. We developed simulation based mathematical tool to investigate the effects of social contact networks on pathogen dissemination in a setting analogous to a daycare center or grade school. Here we show...
Information processing in the retina: computer model and some conclusions
Input-output systems in Biology and Chemistry and a class of mathematical models describing them
Our aim is to show a class of mathematical models in application to some problems of cell biology. Typically, our models are described via classical chemical networks. This property is visualized by a conservation law. Mathematically, this conservation law guarantees most of the mathematical properties of the models such as global existence and uniqueness of solutions as well as positivity of the solutions for positive data. These properties are consequences of the fact that the infinitesimal generators...
Instability of traveling waves for a generalized diffusion model in population problems.
Integrating Photosynthesis, Respiration, Biomass Partitioning, and Plant Growth: Developing a Microsoft Excel®-based Simulation Model of Wisconsin Fast Plant (Brassica rapa, Brassicaceae) Growth with Undergraduate Students
This paper demonstrates the development of a simple model of carbon flow during plant growth. The model was developed by six undergraduate students and their instructor as a project in a plant ecophysiology course. The paper describes the structure of the model including the equations that were used to implement it in Excel®, the plant growth experiments that were conducted to obtain information for parameterizing and testing the model, model performance, student responses to the modeling project,...
Intelligent control of the complex technology process based on adaptive pattern clustering and feature map.
Intensified Doxorubicin-Based Regimen Efficacy in Residual Non-Hodgkin's Lymphoma Disease: Towards a Computationally Supported Treatment Improvement
Despite recent advances, treatment of patients with aggressive Non-Hodgkin's lymphoma (NHL2) has yet to be optimally designed. Notwithstanding the contribution of molecular treatments, intensification of chemotherapeutic regimens may still be beneficial. Hoping to aid in the design of intensified chemotherapy, we put forward a mathematical and computational model that analyses the effect of Doxorubicin on NHL over a wide range of patho-physiological conditions. The model represents tumour growth...
Interchangeability of relevant cycles in graphs.
Interdependence between CHD risk factors examined using linear models with and without transformation of data
Internal exact controllability of the linear population dynamics with diffusion.
Intracellular Modelling of Cell-Matrix Adhesion during Cancer Cell Invasion
When invading the tissue, malignant tumour cells (i.e. cancer cells) need to detach from neighbouring cells, degrade the basement membrane, and migrate through the extracellular matrix. These processes require loss of cell-cell adhesion and enhancement of cell-matrix adhesion. In this paper we present a mathematical model of an intracellular pathway for the interactions between a cancer cell and the extracellular matrix. Cancer cells use similar...
Introducing a scavenger onto a predator prey model.
Invariant subspaces for grasping internal forces and non-interacting force-motion control in robotic manipulation
This paper presents a parametrization of a feed-forward control based on structures of subspaces for a non-interacting regulation. With advances in technological development, robotics is increasingly being used in many industrial sectors, including medical applications (e. g., micro-manipulation of internal tissues or laparoscopy). Typical problems in robotics and general mechanisms may be mathematically formalized and analyzed, resulting in outcomes so general that it is possible to speak of structural...
Invariantes topológicos en el ADN, los Fullerenos y la Teoría de Elección Social.
Inverse modelling of image-based patient-specific blood vessels: zero-pressure geometry and in vivo stress incorporation
In vivo visualization of cardiovascular structures is possible using medical images. However, one has to realize that the resulting 3D geometries correspond to in vivo conditions. This entails an internal stress state to be present in the in vivo measured geometry of e.g. a blood vessel due to the presence of the blood pressure. In order to correct for this in vivo stress, this paper presents an inverse method to restore the original zero-pressure geometry of a structure, and to recover the in vivo...
Inversion of Exponential k-Plane Transforms.