We present the fiber-spring elastic model of the arterial wall with atherosclerotic plaque composed of a lipid pool and a fibrous cap. This model allows us to reproduce pressure to cross-sectional area relationship along the diseased vessel which is used in the network model of global blood circulation. Atherosclerosis attacks a region of systemic arterial network. Our approach allows us to examine the impact of the diseased region onto global haemodynamics....

Cancer has recently overtaken heart disease as the world’s biggest killer. Cancer is initiated by gene mutations that result in local proliferation of abnormal cells and their migration to other parts of the human body, a process called metastasis. The metastasized cancer cells then interfere with the normal functions of the body, eventually leading to death. There are two hundred types of cancer, classified by their point of origin. Most of them...

We present our work on the numerical solution of a continuum model of flocking dynamics in two spatial dimensions. The model consists of the compressible Euler equations with a nonlinear nonlocal term which requires special treatment. We use a semi-implicit discontinuous Galerkin scheme, which proves to be efficient enough to produce results in 2D in reasonable time. This work is a direct extension of the authors' previous work in 1D.

In this paper we present an epidemic model affecting an age-structured population. We show by numerical simulations that this demographic structure can induce persistent oscillations in the epidemic. The model is then extended to encompass a stage-structured disease within an age-dependent population. In this case as well, persistent oscillations are observed in the infected as well as in the whole population.

The dynamics of an activator-inhibitor model with general cubic polynomial source is investigated. Without diffusion, we consider the existence, stability and bifurcations of equilibria by both eigenvalue analysis and numerical methods. For the reaction-diffusion system, a Lyapunov functional is proposed to declare the global stability of constant steady states, moreover, the condition related to the activator source leading to Turing instability is obtained in the paper. In addition, taking the...

Space-time approximations of the FitzHugh–Nagumo system of coupled semi-linear parabolic PDEs are examined. The schemes under consideration are discontinuous in time but conforming in space and of arbitrary order. Stability estimates are presented in the natural energy norms and at arbitrary times, under minimal regularity assumptions. Space-time error estimates of arbitrary order are derived, provided that the natural parabolic regularity is present. Various physical parameters appearing in the...

Space-time approximations of the FitzHugh–Nagumo system of coupled semi-linear parabolic PDEs are examined. The schemes under consideration are discontinuous in time but conforming in space and of arbitrary order. Stability estimates are presented in the natural energy norms and at arbitrary times, under minimal regularity assumptions. Space-time error estimates of arbitrary order are derived, provided that the natural parabolic regularity is present....

We consider a model of migrating population occupying a compact domain Ω in the plane. We assume the Malthusian growth of the population at each point x ∈ Ω and that the mobility of individuals depends on x ∈ Ω. The evolution of the probability density u(x,t) that a randomly chosen individual occupies x ∈ Ω at time t is described by the nonlocal linear equation $u_t={\int }_{\Omega }\phi \left(y\right)u(y,t)dy-\phi \left(x\right)u(x,t)$, where φ(x) is a given function characterizing the mobility of individuals living at x. We show that the asymptotic behaviour of u(x,t)...

In this paper we study the nonlinear Dirichlet problem involving p(x)-Laplacian (hemivariational inequality) with nonsmooth potential. By using nonsmooth critical point theory for locally Lipschitz functionals due to Chang [6] and the properties of variational Sobolev spaces, we establish conditions which ensure the existence of solution for our problem.

A simple proof of the existence of solutions for the two-dimensional Keller-Segel model with measures with all the atoms less than 8π as the initial data is given. This result was obtained by Senba and Suzuki (2002) and Bedrossian and Masmoudi (2014) using different arguments. Moreover, we show a uniform bound for the existence time of solutions as well as an optimal hypercontractivity estimate.

This paper is concerned with the study of a nonlocal nonlinear parabolic problem associated with the equation $u_t-M\left({\int }_{\Omega }\phi u\mathrm{d}x\right)\mathrm{div}\left(A(x,t,u)\nabla u\right)=g(x,t,u)$ in $\Omega \times (0,T)$, where $\Omega$ is a bounded domain of ${ℝ}^n$$(n\ge 1)$,...

The self-consistent chemotaxis-fluid system $$\left\{\begin{array}{cc}{n}_t+u·\nabla n=\Delta n-\nabla ·\left(n\nabla c\right)+\nabla ·\left(n\nabla \phi \right),\hfill & x\in \Omega ,t>0,\hfill \\ c_t+u·\nabla c=\Delta c-nc,\hfill & x\in \Omega ,t>0,\hfill \\ u_t+\kappa (u·\nabla )u+\nabla P=\Delta u-n\nabla \phi +n\nabla c,\hfill & x\in \Omega ,t>0,\hfill \\ \nabla ·u=0,\hfill & x\in \Omega ,t>0,\hfill \end{array}\right.$$ is considered under no-flux boundary conditions for $n,c$ and the Dirichlet boundary condition for $u$ on a bounded smooth domain $\Omega \subset {ℝ}^N$$(N=2,3...$