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While making informed decisions regarding
investments in customer retention and acquisition becomes a
pressing managerial issue, formal models and analysis, which may
provide insight into this topic, are still scarce. In this study
we examine two dynamic models for optimal acquisition and
retention models of a monopoly, the total cost and the cost per
customer models.
These models are analytically analyzed using classical, direct,
methods and asymptotic expansions (for the total cost model).
In...
The immune system is able to protect the host from tumor onset, and immune deficiencies
are accompanied by an increased risk of cancer. Immunology is one of the fields in biology
where the role of computational and mathematical modeling and analysis were recognized the
earliest, beginning from 60s of the last century. We introduce the two most common methods
in simulating the competition among the immune system, cancers and tumor immunology
strategies:...
We introduce a phenomenological model for anti-angiogenic therapy in the treatment of metastatic cancers. It is a structured transport equation with a nonlocal boundary condition describing the evolution of the density of metastases that we analyze first at the continuous level. We present the numerical analysis of a lagrangian scheme based on the characteristics whose convergence establishes existence of solutions. Then we prove an error estimate and use the model to perform interesting simulations...
We introduce a phenomenological model for anti-angiogenic therapy in the treatment of metastatic cancers. It is a structured transport equation with a nonlocal boundary condition describing the evolution of the density of metastases that we analyze first at the continuous level. We present the numerical analysis of a lagrangian scheme based on the characteristics whose convergence establishes existence of solutions. Then we prove an error estimate and use the model to perform interesting simulations...
We introduce a phenomenological model for anti-angiogenic therapy in the treatment of metastatic cancers. It is a structured transport equation with a nonlocal boundary condition describing the evolution of the density of metastases that we analyze first at the continuous level. We present the numerical analysis of a lagrangian scheme based on the characteristics whose convergence establishes existence of solutions. Then we prove an error estimate and use the model to perform interesting simulations...
In this paper, we consider a multi-lithology diffusion model used in stratigraphic modelling to simulate large scale transport processes of sediments described as a mixture of lithologies. This model is a simplified one for which the surficial fluxes are proportional to the slope of the topography and to a lithology fraction with unitary diffusion coefficients. The main unknowns of the system are the sediment thickness , the surface concentrations in lithology of the sediments at the top...
In this paper, we consider a multi-lithology diffusion model used in stratigraphic modelling to simulate large scale transport processes of sediments described as a mixture of L lithologies.
This model is a simplified one for which the surficial fluxes are proportional
to the slope of the topography and to a lithology fraction with unitary diffusion coefficients.
The main unknowns of the system are the sediment thickness h,
the L surface concentrations in lithology i of the sediments
at the...
This paper is concerned with mathematical and numerical analysis of the system of radiative integral transfer equations. The existence and uniqueness of solution to the integral system is proved by establishing the boundedness of the radiative integral operators and proving the invertibility of the operator matrix associated with the system. A collocation-boundary element method is developed to discretize the differential-integral system. For the non-convex geometries, an element-subdivision algorithm...
This article is devoted to the construction of a mathematical model describing the early
formation of atherosclerotic lesions. The early stage of atherosclerosis is an
inflammatory process that starts with the penetration of low density lipoproteins in the
intima and with their oxidation. This phenomenon is closely linked to the local blood flow
dynamics. Extending a previous work [5] that was mainly restricted to a
one-dimensional setting, we couple...
In this paper we are interested in the numerical modeling
of absorbing ferromagnetic materials
obeying the non-linear Landau-Lifchitz-Gilbert law with respect to the
propagation and scattering of electromagnetic waves.
In this work
we consider the 1D problem.
We first show that the corresponding Cauchy problem
has a unique global solution.
We then derive a numerical scheme based on an appropriate modification
of Yee's scheme, that we show to preserve some important
properties of the continuous...
This contribution is devoted to a new model of HIV multiplication motivated by the patent of one of the authors. We take into account the antigenic diversity through what we define “antigenicity”, whether of the virus or of the adapted lymphocytes. We model the interaction of the immune system and the viral strains by two processes. On the one hand, the presence of a given viral quasi-species generates antigenically adapted lymphocytes. On the other hand, the lymphocytes kill only viruses for which...
Atmospheric flow equations govern the time evolution of chemical concentrations in the
atmosphere. When considering gas and particle phases, the underlying partial differential
equations involve advection and diffusion operators, coagulation effects, and evaporation
and condensation phenomena between the aerosol particles and the gas phase. Operator
splitting techniques are generally used in global air quality models. When considering
organic aerosol...
The paper deals with approximations and the numerical realization of a class of hemivariational inequalities used for modeling of delamination and nonmonotone friction problems. Assumptions guaranteeing convergence of discrete models are verified and numerical results of several model examples computed by a nonsmooth variant of Newton method are presented.
The cancer stem cell hypothesis has evolved to one of the most important paradigms in
biomedical research. During recent years evidence has been accumulating for the existence
of stem cell-like populations in different cancers, especially in leukemias. In the
current work we propose a mathematical model of cancer stem cell dynamics in leukemias. We
apply the model to compare cellular properties of leukemic stem cells to those of their
benign counterparts....
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