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Neural network based identification of hysteresis in human meridian systems

Yonghong Tan, Ruili Dong, Hui Chen, Hong He (2012)

International Journal of Applied Mathematics and Computer Science

Developing a model based digital human meridian system is one of the interesting ways of understanding and improving acupuncture treatment, safety analysis for acupuncture operation, doctor training, or treatment scheme evaluation. In accomplishing this task, how to construct a proper model to describe the behavior of human meridian systems is one of the very important issues. From experiments, it has been found that the hysteresis phenomenon occurs in the relations between stimulation input and...

New Computational Tools for Modeling Chronic Myelogenous Leukemia

M. M. Peet, P. S. Kim, S.-I. Niculescu, D. Levy (2009)

Mathematical Modelling of Natural Phenomena

In this paper, we consider a system of nonlinear delay-differential equations (DDEs) which models the dynamics of the interaction between chronic myelogenous leukemia (CML), imatinib, and the anti-leukemia immune response. Because of the chaotic nature of the dynamics and the sparse nature of experimental data, we look for ways to use computation to analyze the model without employing direct numerical simulation. In particular, we develop several tools using Lyapunov-Krasovskii analysis that allow...

New Resolution Strategy for Multi-scale Reaction Waves using Time Operator Splitting and Space Adaptive Multiresolution: Application to Human Ischemic Stroke*

Max Duarte, Marc Massot, Stéphane Descombes, Christian Tenaud, Thierry Dumont, Violaine Louvet, Frédérique Laurent (2011)

ESAIM: Proceedings

We tackle the numerical simulation of reaction-diffusion equations modeling multi-scale reaction waves. This type of problems induces peculiar difficulties and potentially large stiffness which stem from the broad spectrum of temporal scales in the nonlinear chemical source term as well as from the presence of large spatial gradients in the reactive fronts, spatially very localized. A new resolution strategy was recently introduced ? that combines...

Node assignment problem in Bayesian networks

Joanna Polanska, Damian Borys, Andrzej Polanski (2006)

International Journal of Applied Mathematics and Computer Science

This paper deals with the problem of searching for the best assignments of random variables to nodes in a Bayesian network (BN) with a given topology. Likelihood functions for the studied BNs are formulated, methods for their maximization are described and, finally, the results of a study concerning the reliability of revealing BNs' roles are reported. The results of BN node assignments can be applied to problems of the analysis of gene expression profiles.

Nonlinear Leray-Schauder alternatives and application to nonlinear problem arising in the theory of growing cell population

Afif Amar (2011)

Open Mathematics

Motivated by a mathematical model of an age structured proliferating cell population, we state some new variants of Leray-Schauder type fixed point theorems for (ws)-compact operators. Further, we apply our results to establish some new existence and locality principles for nonlinear boundary value problem arising in the theory of growing cell population in L 1-setting. Besides, a topological structure of the set of solutions is provided.

Nonlinear stabilizing control of an uncertain bioprocess model

Neli Dimitrova, Mikhail Krastanov (2009)

International Journal of Applied Mathematics and Computer Science

In this paper we consider a nonlinear model of a biological wastewater treatment process, based on two microbial populations and two substrates. The model, described by a four-dimensional dynamic system, is known to be practically verified and reliable. First we study the equilibrium points of the open-loop system, their stability and local bifurcations with respect to the control variable. Further we propose a feedback control law for asymptotic stabilization of the closed-loop system towards a...

Nonparametric bivariate estimation for successive survival times.

Carles Serrat, Guadalupe Gómez (2007)

SORT

Several aspects of the analysis of two successive survival times are considered. All the analyses take into account the dependent censoring on the second time induced by the first. Three nonparametric methods are described, implemented and applied to the data coming from a multicentre clinical trial for HIV-infected patients. Visser's and Wang and Wells methods propose an estimator for the bivariate survival function while Gómez and Serrat's method presents a conditional approach for the second...

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