Polymyositis, topological proteomics technology and paradigm for cell invasion dynamics.
Polyomaviridae assembly polymorphism from an energy landscape perspective.
Populational adaptive evolution, chemotherapeutic resistance and multiple anti-cancer therapies
Resistance to chemotherapies, particularly to anticancer treatments, is an increasing medical concern. Among the many mechanisms at work in cancers, one of the most important is the selection of tumor cells expressing resistance genes or phenotypes. Motivated by the theory of mutation-selection in adaptive evolution, we propose a model based on a continuous variable that represents the expression level of a resistance gene (or genes, yielding a phenotype) influencing in healthy and tumor cells birth/death...
Poznámky k výběru proměnných pro vlastní model nervové buňky
Poznámky ke koncepci biologické autoorganizace
Pravděpodobnostní model spontánní vzruchové aktivity neuronu
Pre-symptomatic Influenza Transmission, Surveillance, and School Closings: Implications for Novel Influenza A (H1N1)
Early studies of the novel swine-origin 2009 influenza A (H1N1) epidemic indicate clinical attack rates in children much higher than in adults. Non-medical interventions such as school closings are constrained by their large socio-economic costs. Here we develop a mathematical model to ascertain the roles of pre-symptomatic influenza transmission as well as symptoms surveillance of children to assess the utility of school closures. Our model analysis...
Prevalence of aquatic insects and arsenic concentration determine the geographical distribution of mycobacterium ulcerans infection.
Principal concepts of systems fuzzification. Fuzzification of systems for technical and medical practice. I
Principle of Minimax and Rise Phyllotaxis (Mechanistic Phyllotaxis Model)
Probabilistic interpretation and random walk on spheres algorithms for the Poisson-Boltzmann equation in molecular dynamics
Motivated by the development of efficient Monte Carlo methods for PDE models in molecular dynamics, we establish a new probabilistic interpretation of a family of divergence form operators with discontinuous coefficients at the interface of two open subsets of . This family of operators includes the case of the linearized Poisson-Boltzmann equation used to compute the electrostatic free energy of a molecule. More precisely, we explicitly construct a Markov process whose infinitesimal generator...
Problem poser – how to interpret divergent prognostic evidence of simultaneously measured tumor markers?
Progress in developing Poisson-Boltzmann equation solvers
This review outlines the recent progress made in developing more accurate and efficient solutions to model electrostatics in systems comprised of bio-macromolecules and nanoobjects, the last one referring to objects that do not have biological function themselves but nowadays are frequently used in biophysical and medical approaches in conjunction with bio-macromolecules. The problem of modeling macromolecular electrostatics is reviewed from two different angles: as a mathematical task provided...
Progressive diseases: Interpretation of genetic data.
Propagation of elastic waves in DNA.
Pseudo-analytic finite partition approach to temperature distribution problem in human limbs.
Pulsatile flow of a two-fluid model for blood flow through arterial stenosis.
Pulsatile flow of couple stress fluid through a porous medium with periodic body acceleration and magnetic field.
Pulsatile flow of two-fluid nonlinear models for blood flow through catheterized arteries: a comparative study.