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Nonlinear stabilizing control of an uncertain bioprocess model

Neli Dimitrova, Mikhail Krastanov (2009)

International Journal of Applied Mathematics and Computer Science

In this paper we consider a nonlinear model of a biological wastewater treatment process, based on two microbial populations and two substrates. The model, described by a four-dimensional dynamic system, is known to be practically verified and reliable. First we study the equilibrium points of the open-loop system, their stability and local bifurcations with respect to the control variable. Further we propose a feedback control law for asymptotic stabilization of the closed-loop system towards a...

Nonparametric bivariate estimation for successive survival times.

Carles Serrat, Guadalupe Gómez (2007)

SORT

Several aspects of the analysis of two successive survival times are considered. All the analyses take into account the dependent censoring on the second time induced by the first. Three nonparametric methods are described, implemented and applied to the data coming from a multicentre clinical trial for HIV-infected patients. Visser's and Wang and Wells methods propose an estimator for the bivariate survival function while Gómez and Serrat's method presents a conditional approach for the second...

Numerical simulation of blood flows through a porous interface

Miguel A. Fernández, Jean-Frédéric Gerbeau, Vincent Martin (2008)

ESAIM: Mathematical Modelling and Numerical Analysis

We propose a model for a medical device, called a stent, designed for the treatment of cerebral aneurysms. The stent consists of a grid, immersed in the blood flow and located at the inlet of the aneurysm. It aims at promoting a clot within the aneurysm. The blood flow is modelled by the incompressible Navier-Stokes equations and the stent by a dissipative surface term. We propose a stabilized finite element method for this model and we analyse its convergence in the case of the Stokes...

Numerical simulation of chemotactic bacteria aggregation via mixed finite elements

Americo Marrocco (2003)

ESAIM: Mathematical Modelling and Numerical Analysis - Modélisation Mathématique et Analyse Numérique

We start from a mathematical model which describes the collective motion of bacteria taking into account the underlying biochemistry. This model was first introduced by Keller-Segel [13]. A new formulation of the system of partial differential equations is obtained by the introduction of a new variable (this new variable is similar to the quasi-Fermi level in the framework of semiconductor modelling). This new system of P.D.E. is approximated via a mixed finite element technique. The solution algorithm...

Numerical simulation of chemotactic bacteria aggregation via mixed finite elements

Americo Marrocco (2010)

ESAIM: Mathematical Modelling and Numerical Analysis

We start from a mathematical model which describes the collective motion of bacteria taking into account the underlying biochemistry. This model was first introduced by Keller-Segel [13]. A new formulation of the system of partial differential equations is obtained by the introduction of a new variable (this new variable is similar to the quasi-Fermi level in the framework of semiconductor modelling). This new system of P.D.E. is approximated via a mixed finite element technique. The solution...

Numerical simulation of surface acoustic wave actuated cell sorting

Thomas Franke, Ronald Hoppe, Christopher Linsenmann, Kidist Zeleke (2013)

Open Mathematics

We consider the mathematical modeling and numerical simulation of high throughput sorting of two different types of biological cells (type I and type II) by a biomedical micro-electro-mechanical system (BioMEMS) whose operating behavior relies on surface acoustic wave (SAW) manipulated fluid flow in a microchannel. The BioMEMS consists of a separation channel with three inflow channels for injection of the carrier fluid and the cells, two outflow channels for separation, and an interdigital transducer...

Numerical study of the stopping of aura during migraine

C. Pocci, A. Moussa, F. Hubert, G. Chapuisat (2010)

ESAIM: Proceedings

This work is devoted to the study of migraine with aura in the human brain. Following [6], we class migraine as a propagation of a wave of depolarization through the cells. The mathematical model used, based on a reaction-diffusion equation, is briefly presented. The equation is considered in a duct containing a bend, in order to model one of the numerous circumvolutions of the brain. For a wide set of parameters, one can establish the existence...

Observations on the Pathophysiology and Mechanisms for Cyclic Neutropenia

C. Colijn, D. C. Dale, C. Foley, M. C. Mackey (2010)

Mathematical Modelling of Natural Phenomena

We review the basic pathology of cyclical neutropenia in both humans and the grey collie, and examine the role that mathematical modeling of hematopoietic cell production has played in our understanding of the origins of this fascinating dynamical disease.

On a constrained minimization problem arising in hemodynamics

João Janela, Adélia Sequeira (2008)

Banach Center Publications

Experimental evidence collected over the years shows that blood exhibits non-Newtonian characteristics such as shear-thinning, viscoelasticity, yield stress and thixotropic behaviour. Under certain conditions these characteristics become relevant and must be taken into consideration when modelling blood flow. In this work we deal with incompressible generalized Newtonian fluids, that account for the non-constant viscosity of blood, and present a new numerical method to handle fluid-rigid body interaction...

On a Model of Leukemia Development with a Spatial Cell Distribution

A. Ducrot, V. Volpert (2010)

Mathematical Modelling of Natural Phenomena

In this paper we propose a mathematical model to describe the evolution of leukemia in the bone marrow. The model is based on a reaction-diffusion system of equations in a porous medium. We show the existence of two stationary solutions, one of them corresponds to the normal case and another one to the pathological case. The leukemic state appears as a result of a bifurcation when the normal state loses its stability. The critical conditions of leukemia development are determined by the proliferation...

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