A class of nonlinear viscous transport equations describing aggregation phenomena in biology is considered. General conditions on an interaction potential are obtained which lead either to the existence or to the nonexistence of global-in-time solutions.

This paper is concerned with the two-species chemotaxis-Navier–Stokes system with Lotka–Volterra competitive kinetics $$\begin{array}{c}\hfill \left\{\begin{array}{cc}{\left(1\right)}_t+u·1=𝔻1-{\chi }_1·\left(1c\right)+{\mu }_{1}1(1-1-a_{1}2)\hfill & \text{in}\times (0,\infty ),\hfill \\ {\left(2\right)}_t+u·2=𝔻2-{\chi }_2·\left(2c\right)+{\mu }_{2}2(1-a_{2}1-2)\hfill & \text{in}\times (0,\infty ),\hfill \\ c_t+u·c=𝔻c-(\alpha 1+\beta 2)c\hfill & \text{in}\times (0,\infty ),\hfill \\ u_t+(u·)u=𝔻u+\nabla P+(\gamma 1+2)\Phi ,·u=0\hfill & \text{in}\times (0,\infty )\hfill \end{array}\right.\end{array}$$ under homogeneous Neumann boundary conditions and initial conditions, where is a bounded domain in R3 with smooth boundary. Recently, in the 2-dimensional setting, global existence and stabilization of classical solutions to the above system were first established. However, the 3-dimensional case has not been studied: Because of difficulties in the Navier–Stokes system, we can...

We study a quasilinear parabolic-parabolic chemotaxis system with nonlinear logistic source, under homogeneous Neumann boundary conditions in a smooth bounded domain. By establishing proper a priori estimates we prove that, with both the diffusion function and the chemotaxis sensitivity function being positive, the corresponding initial boundary value problem admits a unique global classical solution which is uniformly bounded. The result of this paper is a generalization of that of Cao (2014).

This paper deals with parabolic-elliptic chemotaxis systems with the sensitivity function $\chi \left(v\right)$ and the growth term $f\left(u\right)$ under homogeneous Neumann boundary conditions in a smooth bounded domain. Here it is assumed that $0<\chi \left(v\right)\le {\chi }_0/v^k$$(k\ge 1...$

Cancer has recently overtaken heart disease as the world’s biggest killer. Cancer is initiated by gene mutations that result in local proliferation of abnormal cells and their migration to other parts of the human body, a process called metastasis. The metastasized cancer cells then interfere with the normal functions of the body, eventually leading to death. There are two hundred types of cancer, classified by their point of origin. Most of them...

In this work, we introduce a new software created to study hematopoiesis at the cell population level with the individually based approach. It can be used as an interface between theoretical works on population dynamics and experimental observations. We show that this software can be useful to study some features of normal hematopoiesis as well as some blood diseases such as myelogenous leukemia. It is also possible to simulate cell communication and the formation of cell colonies in the bone marrow. ...

We consider a quasilinear parabolic system which has the structure of Patlak-Keller-Segel model of chemotaxis and contains a class of models with degenerate diffusion. A cell population is described in terms of volume fraction or density. In the latter case, it is assumed that there is a threshold value which the density of cells cannot exceed. Existence and uniqueness of solutions to the corresponding initial-boundary value problem and existence of space inhomogeneous stationary solutions are discussed....

We classify the global behavior of weak solutions of the Keller-Segel system of degenerate and nondegenerate type. For the stronger degeneracy, the weak solution exists globally in time and has a uniform time decay under some extra conditions. If the degeneracy is weaker, the solution exhibits a finite time blow up if the data is nonnegative. The situation is very similar to the semilinear case. Some additional discussion is also presented.

This paper deals with existence of finite-time blow-up solutions to a degenerate parabolic–elliptic Keller–Segel system with logistic source. Recently, finite-time blow-up was established for a degenerate Jäger–Luckhaus system with logistic source. However, blow-up solutions of the aforementioned system have not been obtained. The purpose of this paper is to construct blow-up solutions of a degenerate Keller–Segel system with logistic source.

A simple proof of the existence of solutions for the two-dimensional Keller-Segel model with measures with all the atoms less than 8π as the initial data is given. This result was obtained by Senba and Suzuki (2002) and Bedrossian and Masmoudi (2014) using different arguments. Moreover, we show a uniform bound for the existence time of solutions as well as an optimal hypercontractivity estimate.

This paper is concerned with blow-up of solutions to a two-species chemotaxis-competition model with production from only one species. In previous papers there are a lot of studies on boundedness for a two-species chemotaxis-competition model with productions from both two species. On the other hand, finite-time blow-up was recently obtained under smallness conditions for competitive effects. Now, in the biological view, the production term seems to promote blow-up phenomena; this implies that the...

The self-consistent chemotaxis-fluid system $$\left\{\begin{array}{cc}{n}_t+u·\nabla n=\Delta n-\nabla ·\left(n\nabla c\right)+\nabla ·\left(n\nabla \phi \right),\hfill & x\in \Omega ,t>0,\hfill \\ c_t+u·\nabla c=\Delta c-nc,\hfill & x\in \Omega ,t>0,\hfill \\ u_t+\kappa (u·\nabla )u+\nabla P=\Delta u-n\nabla \phi +n\nabla c,\hfill & x\in \Omega ,t>0,\hfill \\ \nabla ·u=0,\hfill & x\in \Omega ,t>0,\hfill \end{array}\right.$$ is considered under no-flux boundary conditions for $n,c$ and the Dirichlet boundary condition for $u$ on a bounded smooth domain $\Omega \subset {ℝ}^N$$(N=2,3...$

A model of chemotaxis is analyzed that prevents blow-up of solutions. The model consists of a system of nonlinear partial differential equations for the spatial population density of a species and the spatial concentration of a chemoattractant in n-dimensional space. We prove the existence of solutions, which exist globally, and are L∞-bounded on finite time intervals. The hypotheses require nonlocal conditions on the species-induced production of the chemoattractant.

In this paper we consider a model of chemorepulsion. We prove global existence and uniqueness of smooth classical solutions in space dimension n = 2. For n = 3,4 we prove the global existence of weak solutions. The convergence to steady states is shown in all cases.

A system of quasilinear parabolic equations modelling chemotaxis and taking into account the volume filling effect is studied under no-flux boundary conditions. The resulting system is non-uniformly parabolic. A Lyapunov functional for the system is constructed. The proof of existence and uniqueness of regular global-in-time solutions is given in cases when either the Lyapunov functional is bounded from below or chemotactic forces are suitably weakened. In the first case solutions are uniformly...

We study the chemotaxis system with singular sensitivity and logistic-type source: $u_t=\Delta u-\chi \nabla ·(u\nabla v/v)+ru-\mu u^k$, $0=\Delta v-v+u$ under the non-flux boundary conditions in a smooth bounded domain $\Omega \subset {ℝ}^n$, $\chi ,r,\mu >0$, $k>1$ and $n\ge 1$. It is shown with $k\in (1,2)$ that the system possesses a global generalized solution for $n\ge 2$ which is bounded when $\chi >0$ is suitably small related to $r>0$ and the initial datum is properly small, and a global bounded classical solution for $n=1$.

We investigate a model describing the dynamics of a gas of self-gravitating Brownian particles. This model can also have applications for the chemotaxis of bacterial populations. We focus here on the collapse phase obtained at sufficiently low temperature/energy and on the post-collapse regime following the singular time where the central density diverges. Several analytical results are illustrated by numerical simulations.

Cell motility is an integral part of a diverse set of biological processes. The quest for mathematical models of cell motility has prompted the development of automated approaches for gathering quantitative data on cell morphology, and the distribution of molecular players involved in cell motility. Here we review recent approaches for quantifying cell motility, including automated cell segmentation and tracking. Secondly, we present our own novel...