Mathematical model of an immune system with random time of reaction
In this paper, we propose a mathematical model for flow and transport processes of diluted solutions in domains separated by a leaky semipermeable membrane. We formulate transmission conditions for the flow and the solute concentration across the membrane which take into account the property of the membrane to partly reject the solute, the accumulation of rejected solute at the membrane, and the influence of the solute concentration on the volume flow, known as osmotic effect. The model is solved...
This contribution is devoted to a new model of HIV multiplication motivated by the patent of one of the authors. We take into account the antigenic diversity through what we define “antigenicity”, whether of the virus or of the adapted lymphocytes. We model the interaction of the immune system and the viral strains by two processes. On the one hand, the presence of a given viral quasi-species generates antigenically adapted lymphocytes. On the other hand, the lymphocytes kill only viruses for which...
The cancer stem cell hypothesis has evolved to one of the most important paradigms in biomedical research. During recent years evidence has been accumulating for the existence of stem cell-like populations in different cancers, especially in leukemias. In the current work we propose a mathematical model of cancer stem cell dynamics in leukemias. We apply the model to compare cellular properties of leukemic stem cells to those of their benign counterparts....
Recent discovery of cancer stem cells in tumorigenic tissues has raised many questions about their nature, origin, function and their behavior in cell culture. Most of current experiments reporting a dynamics of cancer stem cell populations in culture show the eventual stability of the percentages of these cell populations in the whole population of cancer cells, independently of the starting conditions. In this paper we propose a mathematical model...
We address here mathematical models related to the Laser-Plasma Interaction. After a simplified introduction to the physical background concerning the modelling of the laser propagation and its interaction with a plasma, we recall some classical results about the geometrical optics in plasmas. Then we deal with the well known paraxial approximation of the solution of the Maxwell equation; we state a coupling model between the plasma hydrodynamics and the laser propagation. Lastly, we consider the...
We address here mathematical models related to the Laser-Plasma Interaction. After a simplified introduction to the physical background concerning the modelling of the laser propagation and its interaction with a plasma, we recall some classical results about the geometrical optics in plasmas. Then we deal with the well known paraxial approximation of the solution of the Maxwell equation; we state a coupling model between the plasma hydrodynamics and the laser propagation. Lastly, we consider the...
Flow cytometric analysis using intracellular dyes such as CFSE is a powerful experimental tool which can be used in conjunction with mathematical modeling to quantify the dynamic behavior of a population of lymphocytes. In this survey we begin by providing an overview of the mathematically relevant aspects of the data collection procedure. We then present an overview of the large body of mathematical models, along with their assumptions and uses,...
Etant donné un système différentiel linéaire de niveau unique quelconque, nous explicitons des formules donnant les multiplicateurs de Stokes en fonction de constantes de connexion dans le plan de Borel, généralisant ainsi les formules obtenues dans l’article Resurgence, Stokes phenomenon and alien derivatives for level-one linear differential systems (M. Loday-Richaud, P. Remy). Pour ce faire, nous nous ramenons à un système de niveaux par la méthode classique de réduction du rang ; puis, nous...