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A Mathematical Model of Cancer Stem Cell Lineage Population Dynamics with Mutation Accumulation and Telomere Length Hierarchies

G. Kapitanov (2012)

Mathematical Modelling of Natural Phenomena

There is evidence that cancer develops when cells acquire a sequence of mutations that alter normal cell characteristics. This sequence determines a hierarchy among the cells, based on how many more mutations they need to accumulate in order to become cancerous. When cells divide, they exhibit telomere loss and differentiate, which defines another cell hierarchy, on top of which is the stem cell. We propose a mutation-generation model, which combines...

A mathematical model of inflammation during ischemic stroke

Cristiana Di Russo, Jean-Baptiste Lagaert, Guillemette Chapuisat, Marie-Aimée Dronne (2010)

ESAIM: Proceedings

In this article we propose a model to describe the inflammatory process which occurs during ischemic stroke. First, an introduction to some basic concepts about the biological phenomenon is given. Then, a detailed derivation of the model and the numerical scheme used are presented. Finally, the studies of the model robustness and sensitivity are showed and some numerical results on the time and space evolution of the process are presented and discussed....

A mixed finite element method for Darcy flow in fractured porous media with non-matching grids

Carlo D’Angelo, Anna Scotti (2012)

ESAIM: Mathematical Modelling and Numerical Analysis - Modélisation Mathématique et Analyse Numérique

We consider an incompressible flow problem in a N-dimensional fractured porous domain (Darcy’s problem). The fracture is represented by a (N − 1)-dimensional interface, exchanging fluid with the surrounding media. In this paper we consider the lowest-order (ℝ T0, ℙ0) Raviart-Thomas mixed finite element method for the approximation of the coupled Darcy’s flows in the porous media and within the fracture, with independent meshes for the respective domains. This is achieved thanks to an enrichment...

A mixed finite element method for Darcy flow in fractured porous media with non-matching grids∗

Carlo D’Angelo, Anna Scotti (2011)

ESAIM: Mathematical Modelling and Numerical Analysis

We consider an incompressible flow problem in a N-dimensional fractured porous domain (Darcy’s problem). The fracture is represented by a (N − 1)-dimensional interface, exchanging fluid with the surrounding media. In this paper we consider the lowest-order (ℝ T0, ℙ0) Raviart-Thomas mixed finite element method for the approximation of the coupled Darcy’s flows in the porous media and within the fracture, with independent meshes for the respective...

A multi-D model for Raman amplification

Mathieu Colin, Thierry Colin (2011)

ESAIM: Mathematical Modelling and Numerical Analysis - Modélisation Mathématique et Analyse Numérique

In this paper, we continue the study of the Raman amplification in plasmas that we initiated in [Colin and Colin, Diff. Int. Eqs. 17 (2004) 297–330; Colin and Colin, J. Comput. Appl. Math. 193 (2006) 535–562]. We point out that the Raman instability gives rise to three components. The first one is collinear to the incident laser pulse and counter propagates. In 2-D, the two other ones make a non-zero angle with the initial pulse and propagate forward. Furthermore they are symmetric with respect...

A multi-D model for Raman amplification

Mathieu Colin, Thierry Colin (2011)

ESAIM: Mathematical Modelling and Numerical Analysis

In this paper, we continue the study of the Raman amplification in plasmas that we initiated in [Colin and Colin, Diff. Int. Eqs.17 (2004) 297–330; Colin and Colin, J. Comput. Appl. Math.193 (2006) 535–562]. We point out that the Raman instability gives rise to three components. The first one is collinear to the incident laser pulse and counter propagates. In 2-D, the two other ones make a non-zero angle with the initial pulse and propagate forward. Furthermore they are symmetric with respect to...

A multidimensional singular stochastic control problem on a finite time horizon

Marcin Boryc, Łukasz Kruk (2015)

Annales UMCS, Mathematica

A singular stochastic control problem in n dimensions with timedependent coefficients on a finite time horizon is considered. We show that the value function for this problem is a generalized solution of the corresponding HJB equation with locally bounded second derivatives with respect to the space variables and the first derivative with respect to time. Moreover, we prove that an optimal control exists and is unique

A multilayer Saint-Venant system with mass exchanges for shallow water flows. Derivation and numerical validation

Emmanuel Audusse, Marie-Odile Bristeau, Benoît Perthame, Jacques Sainte-Marie (2011)

ESAIM: Mathematical Modelling and Numerical Analysis - Modélisation Mathématique et Analyse Numérique

The standard multilayer Saint-Venant system consists in introducing fluid layers that are advected by the interfacial velocities. As a consequence there is no mass exchanges between these layers and each layer is described by its height and its average velocity. Here we introduce another multilayer system with mass exchanges between the neighboring layers where the unknowns are a total height of water and an average velocity per layer. We derive it from Navier-Stokes system with an hydrostatic pressure...

A multilayer Saint-Venant system with mass exchanges for shallow water flows. Derivation and numerical validation*

Emmanuel Audusse, Marie-Odile Bristeau, Benoît Perthame, Jacques Sainte-Marie (2011)

ESAIM: Mathematical Modelling and Numerical Analysis

The standard multilayer Saint-Venant system consists in introducing fluid layers that are advected by the interfacial velocities. As a consequence there is no mass exchanges between these layers and each layer is described by its height and its average velocity. Here we introduce another multilayer system with mass exchanges between the neighboring layers where the unknowns are a total height of water and an average velocity per layer. We derive it from Navier-Stokes system with an hydrostatic...

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