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A Mathematical Model of Cancer Stem Cell Lineage Population Dynamics with Mutation Accumulation and Telomere Length Hierarchies

G. Kapitanov (2012)

Mathematical Modelling of Natural Phenomena

There is evidence that cancer develops when cells acquire a sequence of mutations that alter normal cell characteristics. This sequence determines a hierarchy among the cells, based on how many more mutations they need to accumulate in order to become cancerous. When cells divide, they exhibit telomere loss and differentiate, which defines another cell hierarchy, on top of which is the stem cell. We propose a mutation-generation model, which combines...

A mathematical model of inflammation during ischemic stroke

Cristiana Di Russo, Jean-Baptiste Lagaert, Guillemette Chapuisat, Marie-Aimée Dronne (2010)

ESAIM: Proceedings

In this article we propose a model to describe the inflammatory process which occurs during ischemic stroke. First, an introduction to some basic concepts about the biological phenomenon is given. Then, a detailed derivation of the model and the numerical scheme used are presented. Finally, the studies of the model robustness and sensitivity are showed and some numerical results on the time and space evolution of the process are presented and discussed....

A mixed finite element method for Darcy flow in fractured porous media with non-matching grids

Carlo D’Angelo, Anna Scotti (2012)

ESAIM: Mathematical Modelling and Numerical Analysis - Modélisation Mathématique et Analyse Numérique

We consider an incompressible flow problem in a N-dimensional fractured porous domain (Darcy’s problem). The fracture is represented by a (N − 1)-dimensional interface, exchanging fluid with the surrounding media. In this paper we consider the lowest-order (ℝ T0, ℙ0) Raviart-Thomas mixed finite element method for the approximation of the coupled Darcy’s flows in the porous media and within the fracture, with independent meshes for the respective domains. This is achieved thanks to an enrichment...

A mixed finite element method for Darcy flow in fractured porous media with non-matching grids∗

Carlo D’Angelo, Anna Scotti (2011)

ESAIM: Mathematical Modelling and Numerical Analysis

We consider an incompressible flow problem in a N-dimensional fractured porous domain (Darcy’s problem). The fracture is represented by a (N − 1)-dimensional interface, exchanging fluid with the surrounding media. In this paper we consider the lowest-order (ℝ T0, ℙ0) Raviart-Thomas mixed finite element method for the approximation of the coupled Darcy’s flows in the porous media and within the fracture, with independent meshes for the respective...

A modified Fletcher-Reeves conjugate gradient method for unconstrained optimization with applications in image restoration

Zainab Hassan Ahmed, Mohamed Hbaib, Khalil K. Abbo (2024)

Applications of Mathematics

The Fletcher-Reeves (FR) method is widely recognized for its drawbacks, such as generating unfavorable directions and taking small steps, which can lead to subsequent poor directions and steps. To address this issue, we propose a modification to the FR method, and then we develop it into the three-term conjugate gradient method in this paper. The suggested methods, named ``HZF'' and ``THZF'', preserve the descent property of the FR method while mitigating the drawbacks. The algorithms incorporate...

A multi-D model for Raman amplification

Mathieu Colin, Thierry Colin (2011)

ESAIM: Mathematical Modelling and Numerical Analysis - Modélisation Mathématique et Analyse Numérique

In this paper, we continue the study of the Raman amplification in plasmas that we initiated in [Colin and Colin, Diff. Int. Eqs. 17 (2004) 297–330; Colin and Colin, J. Comput. Appl. Math. 193 (2006) 535–562]. We point out that the Raman instability gives rise to three components. The first one is collinear to the incident laser pulse and counter propagates. In 2-D, the two other ones make a non-zero angle with the initial pulse and propagate forward. Furthermore they are symmetric with respect...

A multi-D model for Raman amplification

Mathieu Colin, Thierry Colin (2011)

ESAIM: Mathematical Modelling and Numerical Analysis

In this paper, we continue the study of the Raman amplification in plasmas that we initiated in [Colin and Colin, Diff. Int. Eqs.17 (2004) 297–330; Colin and Colin, J. Comput. Appl. Math.193 (2006) 535–562]. We point out that the Raman instability gives rise to three components. The first one is collinear to the incident laser pulse and counter propagates. In 2-D, the two other ones make a non-zero angle with the initial pulse and propagate forward. Furthermore they are symmetric with respect to...

A multidimensional singular stochastic control problem on a finite time horizon

Marcin Boryc, Łukasz Kruk (2015)

Annales UMCS, Mathematica

A singular stochastic control problem in n dimensions with timedependent coefficients on a finite time horizon is considered. We show that the value function for this problem is a generalized solution of the corresponding HJB equation with locally bounded second derivatives with respect to the space variables and the first derivative with respect to time. Moreover, we prove that an optimal control exists and is unique

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