Optimal control of combined therapy in a single strain HIV-1 model.
We consider optimal control problems for the bidomain equations of cardiac electrophysiology together with two-variable ionic models, e.g. the Rogers–McCulloch model. After ensuring the existence of global minimizers, we provide a rigorous proof for the system of first-order necessary optimality conditions. The proof is based on a stability estimate for the primal equations and an existence theorem for weak solutions of the adjoint system.
A distributed optimal control problem on and inside a homogeneous skin tissue is solved subject to Pennes' equation with Dirichlet boundary condition at one end and Rubin condition at the other end. The point heating power induced by conducting heating probe inserted at the tumour site as an unknown control function at specific depth inside biological body is preassigned. Corresponding pseudo-port Hamiltonian system is proposed. Moreover, it is proved that bioheat transfer equation forms a contraction...
We consider a size structured cell population model where a mother cell gives birth to two daughter cells. We know that the asymptotic behavior of the density of cells is given by the solution to an eigenproblem. The eigenvector gives the asymptotic shape and the eigenvalue gives the exponential growth rate and so the Maltusian parameter. The Maltusian parameter depends on the division rule for the mother cell, i.e., symmetric (the two daughter cells have the same size) or asymmetric. We use a...
The scheduling of angiogenic inhibitors to control a vascularized tumor is analyzed as an optimal control problem for a mathematical model that was developed and biologically validated by Hahnfeldt et al. [Cancer Res. 59 (1999)]. Two formulations of the problem are considered. In the first one the primary tumor volume is minimized for a given amount of angiogenic inhibitors to be administered, while a balance between tumor reduction and the total amount of angiogenic inhibitors given is minimized...
The chronotherapy concept takes advantage of the circadian rhythm of cells physiology in maximising a treatment efficacy on its target while minimising its toxicity on healthy organs. The object of the present paper is to investigate mathematically and numerically optimal strategies in cancer chronotherapy. To this end a mathematical model describing the time evolution of efficiency and toxicity of an oxaliplatin anti-tumour treatment has been derived. We then applied an optimal control technique...
The chronotherapy concept takes advantage of the circadian rhythm of cells physiology in maximising a treatment efficacy on its target while minimising its toxicity on healthy organs. The object of the present paper is to investigate mathematically and numerically optimal strategies in cancer chronotherapy. To this end a mathematical model describing the time evolution of efficiency and toxicity of an oxaliplatin anti-tumour treatment has been derived. We then applied an optimal control...
The Bidomain model is nowadays one of the most accurate mathematical descriptions of the action potential propagation in the heart. However, its numerical approximation is in general fairly expensive as a consequence of the mathematical features of this system. For this reason, a simplification of this model, called Monodomain problem is quite often adopted in order to reduce computational costs. Reliability of this model is however questionable, in particular in the presence of applied currents...
The Bidomain model is nowadays one of the most accurate mathematical descriptions of the action potential propagation in the heart. However, its numerical approximation is in general fairly expensive as a consequence of the mathematical features of this system. For this reason, a simplification of this model, called Monodomain problem is quite often adopted in order to reduce computational costs. Reliability of this model is however questionable, in particular in the presence of applied currents...
The propagation of the action potential in the heart chambers is accurately described by the Bidomain model, which is commonly accepted and used in the specialistic literature. However, its mathematical structure of a degenerate parabolic system entails high computational costs in the numerical solution of the associated linear system. Domain decomposition methods are a natural way to reduce computational costs, and Optimized Schwarz Methods have proven in the recent years their effectiveness in...
A mathematical model for a problem of blood perfusion in a living tissue through a system of parallel capillaries is studied. Oxygen is assumed to be transported in two forms: freely diffusing and bounded (to erytrocytes in blood, to myoglobin in tissue). Existence of a weak solution is proved and a homogensation procedure is carried out in the case of randomly distribuited capillaries.