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Mechanisms of Cell Motion in Confined Geometries

R. J. Hawkins, R. Voituriez (2010)

Mathematical Modelling of Natural Phenomena

We present a simple mechanism of cell motility in a confined geometry, inspired by recent motility assays in microfabricated channels. This mechanism relies mainly on the coupling of actin polymerisation at the cell membrane to geometric confinement. We first show analytically using a minimal model of polymerising viscoelastic gel confined in a narrow channel that spontaneous motion occurs due to polymerisation alone. Interestingly, this mechanism...

Medical image – based computational model of pulsatile flow in saccular aneurisms

Stéphanie Salmon, Marc Thiriet, Jean-Frédéric Gerbeau (2003)

ESAIM: Mathematical Modelling and Numerical Analysis - Modélisation Mathématique et Analyse Numérique

Saccular aneurisms, swelling of a blood vessel, are investigated in order (i) to estimate the development risk of the wall lesion, before and after intravascular treatment, assuming that the pressure is the major factor, and (ii) to better plan medical interventions. Numerical simulations, using the finite element method, are performed in three-dimensional aneurisms. Computational meshes are derived from medical imaging data to take into account both between-subject and within-subject anatomical...

Medical image – based computational model of pulsatile flow in saccular aneurisms

Stéphanie Salmon, Marc Thiriet, Jean-Frédéric Gerbeau (2010)

ESAIM: Mathematical Modelling and Numerical Analysis

Saccular aneurisms, swelling of a blood vessel, are investigated in order (i) to estimate the development risk of the wall lesion, before and after intravascular treatment, assuming that the pressure is the major factor, and (ii) to better plan medical interventions. Numerical simulations, using the finite element method, are performed in three-dimensional aneurisms. Computational meshes are derived from medical imaging data to take into account both between-subject and within-subject anatomical...

Model based analysis of signaling pathways

Jarosław Smieja (2008)

International Journal of Applied Mathematics and Computer Science

The paper is concerned with application of mathematical modeling to the analysis of signaling pathways. Two issues, deterministic modeling of gene transcription and model-driven discovery of regulatory elements, are dealt with. First, the biological background is given and the importance of the stochastic nature of biological processes is addressed. The assumptions underlying deterministic modeling are presented. Special emphasis is put on describing gene transcription. A framework for including...

Modeling and Simulating Asymmetrical Conductance Changes in Gramicidin Pores

Shixin Xu, Minxin Chen, Sheereen Majd, Xingye Yue, Chun Liu (2014)

Molecular Based Mathematical Biology

Gramicidin A is a small and well characterized peptide that forms an ion channel in lipid membranes. An important feature of gramicidin A (gA) pore is that its conductance is affected by the electric charges near the its entrance. This property has led to the application of gramicidin A as a biochemical sensor for monitoring and quantifying a number of chemical and enzymatic reactions. Here, a mathematical model of conductance changes of gramicidin A pores in response to the presence of electrical...

Modeling and simulation of a blood pump for the development of a left ventricular assist system controller

Yih-Choung Yu, J. Robert Boston, Marwan A. Simaan, Phil J. Miller, James F. Antaki (1999)

Kybernetika

A mathematical model describing the pressure-volume relationship of the Novacor left ventricular assist system (LVAS) was developed. The model consisted of lumped resistance, capacitance, and inductance elements with one time-varying capacitor to simulate the cyclical pressure generation of the system. The ejection and filling portions of the pump cycle were modeled with two separate functions. The corresponding model parameters were estimated by least squares fit to experimental data obtained in...

Modeling Morphogenesis in silico and in vitro: Towards Quantitative, Predictive, Cell-based Modeling

R. M. H. Merks, P. Koolwijk (2009)

Mathematical Modelling of Natural Phenomena

Cell-based, mathematical models help make sense of morphogenesis—i.e. cells organizing into shape and pattern—by capturing cell behavior in simple, purely descriptive models. Cell-based models then predict the tissue-level patterns the cells produce collectively. The first step in a cell-based modeling approach is to isolate sub-processes, e.g. the patterning capabilities of one or a few cell types in cell cultures. Cell-based models can then identify the mechanisms responsible for patterning in...

Modeling of the oxygen transfer in the respiratory process

Sébastien Martin, Bertrand Maury (2013)

ESAIM: Mathematical Modelling and Numerical Analysis - Modélisation Mathématique et Analyse Numérique

In this article, we propose an integrated model for oxygen transfer into the blood, coupled with a lumped mechanical model for the ventilation process. Objectives. We aim at investigating oxygen transfer into the blood at rest or exercise. The first task consists in describing nonlinear effects of the oxygen transfer under normal conditions. We also include the possible diffusion limitation in oxygen transfer observed in extreme regimes involving parameters such as alveolar and venous blood oxygen...

Modeling Pulsatility in the Human Cardiovascular System

de los Reyes V, Aurelio, Kappel, Franz (2010)

Mathematica Balkanica New Series

AMS Subj. Classification: 92C30In this study we investigated, modified and combined two existing mathematical cardiovascular models, a non-pulsatile global model and a simplified pulsatile left heart model. The first goal of the study was to integrate these models. The main objective is to have a global lumped parameter pulsatile model that predicts the pressures in the systemic and pulmonary circulation, and specifically the pulsatile pressures in the the finger arteries where real-time measurements...

Currently displaying 41 – 60 of 107